SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
Pursuant to Section 13 or 15(d)
of the Securities Exchange Act of 1934
Date of Report (Date of earliest event reported): January 7, 2019
Sarepta Therapeutics, Inc.
(Exact name of registrant as specified in its charter)
(State or other Jurisdiction
215 First Street
Cambridge, MA 02142
(Address of principal executive offices, including zip code)
(Registrants Telephone Number, Including Area Code)
(Former Name or Former Address, if Changed Since Last Report)
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instructions A.2. below):
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
Indicate by check mark whether the registrant is an emerging growth company as defined in as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).
Emerging growth company ☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐
|Item 2.02|| |
Results of Operations and Financial Condition.
On January 7, 2019, Douglas S. Ingram, President and Chief Executive Officer of Sarepta Therapeutics, Inc. (the Company) disclosed certain preliminary financial information for the year ended December 31, 2018 during the Companys presentation at the 37th Annual J.P. Morgan Healthcare Conference (the Conference) and in discussions with third parties at the Conference. Specifically, the Company disclosed its cash position of $1.1 billion as of December 31, 2018 and that the Company generated approximately $84.4 million in revenue (unaudited) in the fourth quarter ended December 31, 2018, and approximately $301 million in revenue (unaudited) in the year ended December 31, 2018 from sales of EXONDYS 51® (eteplirsen) Injection. A copy of the slide presentation associated with this announcement is furnished as Exhibit 99.1 and is incorporated herein by reference.
The information in this Item 2.02 is unaudited and preliminary, and does not present all information necessary for an understanding of the Companys financial condition as of December 31, 2018 and its results of operations for the three months and year ended December 31, 2018. The audit of the Companys financial statements for the year ended December 31, 2018 is ongoing and could result in changes to the information in this Item 2.02.
|Item 7.01|| |
Regulation FD Disclosure.
The disclosure in Item 2.02 above is hereby incorporated by reference into this Item 7.01.
The slides presented by Mr. Ingram at the Conference on January 7, 2019 are furnished with this report as Exhibit 99.1, which is incorporated herein by reference.
The information in this report and Exhibit 99.1 to this report is furnished pursuant to Items 2.02 and 7.01 and shall not be deemed filed for the purposes of Section 18 of the Securities and Exchange Act of 1934, as amended (the Exchange Act), or otherwise subject to the liabilities of that section. It may only be incorporated by reference in another filing under the Exchange Act or the Securities Act of 1933, as amended, if such subsequent filing specifically references the information furnished pursuant to Items 2.02 and 7.01 of this report.
|Item 9.01|| |
Financial Statements and Exhibits.
|99.1||Sarepta Therapeutics, Inc. Presentation at the 37th Annual J.P. Morgan Healthcare Conference, dated January 7, 2019.|
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
|Sarepta Therapeutics, Inc.|
|Douglas S. Ingram|
|President and Chief Executive Officer|
Date: January 7, 2019
37th Annual J.P. Morgan Healthcare Conference, San Francisco, CA, January 7, 2019 Doug Ingram President and CEO, Sarepta Therapeutics, Inc. Exhibit 99.1
FORWARD LOOKING STATEMENTS This presentation contains "forward‐looking statements" within the meaning of the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995. Statements that are not historical facts or words such as "believes," "anticipates," "plans," "expects," "will," "intends," "potential," "possible," “goal,” ”strategy,” ”may,” “should,” “project,” “estimate,” and similar expressions are intended to identify forward‐looking statements. Forward‐looking statements in this presentation include but are not limited to: Sarepta’s pipeline, programs and technologies and their respective potential benefits, including the benefits of MHCK7, AAVrh74, SR2 and SR3; the expectation to commercialize golodirsen in 2019 and to have 3 RNA-therapies on the market by 2020, serving approximately 30% of the DMD community; our plan to take scientific advise with EMA in connection with eteplirsen; our intention to play a central role in transforming the health core ecosystem; our opportunities with genetic medicine and in particular gene therapy; our goal to build a gene therapy engine; our expected path forward in connection with our micro-dystrophin program; the potential of gene therapy to upend the traditional R&D model and our intention to play a central role in that upending; the potential of gene therapy to have a higher probability of success from much earlier phase and shorter timelines; our goal to have more commercial supply in the next two years than all of the gene therapy manufacturing supply that exists in the world today; the estimated number of patients suffering from DMD, LGMD and CMT; Sarepta having the most robust precision genetic medicine pipeline in the world; our goal to continue to build our pipeline out and to have 40 programs; the potential of our programs to bring a better life to some portion of the patients living with rare diseases covered by our programs; our milestones and expected timelines, including a target approval for golodirsen in Q3 of 2019, filing for casimersen by mid 2019 with a target approval by Q1 2020, commencing a confirmatory trial for our micro-dystrophin program later in 2019, having results in LGMD in Q1 2019, dosing later in 2019 in our program to treat CMT and commencing dosing in our program to treat MPS3A in Q1 2019; and other statements made during the presentation regarding Sarepta’s future, strategy and business plans. These forward‐looking statements involve risks and uncertainties, many of which are beyond Sarepta’s control and are based on Sarepta’s current beliefs, expectations and assumptions regarding it business. Actual results and financial condition could materially differ from those stated or implied by these forward‐looking statements as a result of such risks and uncertainties and could materially and adversely affect Sarepta’s business, results of operations and trading price. Potential known risk factors include, among others, the following: the audit of our financial statements for the year ended December 31, 2018 is ongoing and could result in changes to the information; we may not be able to meet expectations with respect to EXONDYS 51 sales, profitability or positive cash‐flow from operations; we may not be able to comply with all FDA post‐approval commitments/requirements with respect to EXONDYS 51 in a timely manner or at all; we may not be able to obtain regulatory approval for eteplirsen in jurisdictions outside of the U.S., including from the EMA; our data for golodirsen, casimersen and/or our micro-dystrophin program may not be sufficient for obtaining regulatory approval; our product candidates, including those with strategic partners, may not result in viable treatments suitable for commercialization due to a variety of reasons including the results of future research may not be consistent with past positive results or may fail to meet regulatory approval requirements for the safety and efficacy of product candidates; success in preclinical testing and early clinical trials, especially if based on a small patient sample, does not ensure that later clinical trials will be successful; if the actual number of patients suffering from DMD, LGMD, and/or CMT is smaller than estimated, our revenue and ability to achieve profitability may be adversely affected; our dependence on our manufacturers to fulfill our needs for our clinical trials and commercial supply, including any inability on our part to accurately anticipate product demand and timely secure manufacturing capacity to meet product demand, may impair the availability of products to successfully support various programs, including research and development and the potential commercialization of our gene therapy product candidates; we may not be able to successfully scale up manufacturing of our product candidates in sufficient quality and quantity or within sufficient timelines; we may not be able to execute on our business plans and goals, including meeting our expected or planned regulatory milestones and timelines, clinical development plans, and bringing our product candidates to market, for various reasons including possible limitations of our financial and other resources, manufacturing limitations that may not be anticipated or resolved for in a timely manner, results of research and development efforts and/or clinical trials may not be positive, and regulatory, court or agency decisions, such as decisions by the United States Patent and Trademark Office; and those risks identified under the heading “Risk Factors” in Sarepta’s 2017 Annual Report on Form 10‐K or and most recent Quarterly Report on Form 10‐Q filed with the Securities and Exchange Commission (SEC) and in its other SEC filings. For a detailed description of risks and uncertainties Sarepta faces, you are encouraged to review Sarepta's filings with the SEC. We caution investors not to place considerable reliance on the forward‐looking statements contained in this presentation. The forward‐looking statements in this presentation are made as of the date of this presentation only and, other than as required under applicable law, Sarepta does not undertake any obligation to publicly update its forward‐looking statements.
OUR GOALS FOR 2018 Build out our pipeline Ensure we have the resources to build for the future Clarify a pathway for our RNA technology Become one of the most important rare disease companies Have another strong year of commercial execution
* ** EXPANSION OF OUR RNA AND GENE THERAPY ENGINE 15 PROGRAMS 25 PROGRAMS
Resources and talent* TALENT 2x PhDs 3x MDs Leading gene therapy team 500+ PROFESSIONALS >$1.1B CASH POSITION *As of December 31, 2018; preliminary and unaudited results
Casimersen 2020 Golodirsen 2019 If successful, we will have 3 RNA-therapies by 2020, serving ~30% of the DMD community. 2016 DEFINED RNA PATHWAY
execution FY’17 $154.6M 2016 LAUNCH 2018 GROWTH Q4’18* $84.4M FY’18* $301M *Preliminary and unaudited results
TOP 5 RARE DISEASE COMPANIES* *By Market Cap
We are Sarepta We will change healthcare
AAVrh74 AAVrh74 provides broad distribution to all muscle types, including the heart and diaphragm SR2 and SR3 critical for force production MHCK7 promoter enables robust dystrophin expression in heart and skeletal muscle ITR, inverted tandem repeat; SR, spectral-like repeat. MHCK7 PROMOTER INTRON MICRO-DYSTROPHIN pA ITR ITR Micro-dystrophin program OVERVIEW
Robust expression of micro-dystrophin in muscle fibers Reduction of creatine kinase Improvements across all measured functions*** Well-tolerated * Data from the 4 patients dosed in Study NCT03375164 **NCH Western blot method ***North Star Ambulatory Assessment (NSAA), Time to Rise, 4 Stairs Up, and 100M 81% 96% Normal Control Pre-treatment Post-treatment 78% Robust expression of micro-dystrophin measured by Western blot** and signal intensity UNPRECEDENTED Early stage RESULTS*
Current Trial 24 Patients Placebo controlled Met with FDA in Q4 2018 The path forward Confirmatory Trial With Commercial Material Goal to Commence in 2019 Study Goal Functional Benefit of Expression 2 Patients Started Dosing
And our intent is to do this over and over again
7,000 Rare Diseases ~80% are single gene mutations
7,000 Rare Diseases Impacted Globally 400M Patients And Only 1 FDA Approved GENE THERAPY
10,000s of compounds 250 drug candidates 5 INDs submitted 1 maybe mmm 15 years
Gene therapy can upend this model
MASSIVE OPPORTUNITY TO DO GOOD AND WE WILL PLAY A ROLE IN upending the model PROBABILITY OF SUCCESS TIMELINES
We don’t rely on serendipity We Engineer Solutions PROBABILITY OF SUCCESS
Our manufacturing STRATEGY Paragon Brammer Aldevron In-House Capabilities The largest gene therapy capacity around the globe
Duchenne Muscular Dystrophy Limb-girdle Muscular Dystrophy Charcot-Marie-Tooth Disease Mucopolysaccharidosis Pompe Disease
25 Programs The most robust precision genetic medicine pipeline today 40 Programs Goal >1.5M patients with rare disease globally Epidemiology* MASSIVE OPPORTUNITY TO DO GOOD *Based on published epidemiology
We are upending the model
Because someday is too late
Pulling tomorrow into today