Washington, D.C. 20549


Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB Number: 3235-0104
Estimated average burden
hours per response: 0.5
1. Name and Address of Reporting Person*
Chambers Michael Andrew

(Last) (First) (Middle)


(City) (State) (Zip)
2. Date of Event Requiring Statement (Month/Day/Year)
3. Issuer Name and Ticker or Trading Symbol
Sarepta Therapeutics, Inc. [ SRPT ]
4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
X Director 10% Owner
Officer (give title below) Other (specify below)
5. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
X Form filed by One Reporting Person
Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4) 2. Amount of Securities Beneficially Owned (Instr. 4) 3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock 75,194 I By Revocable Trust
Table II - Derivative Securities Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4) 2. Date Exercisable and Expiration Date (Month/Day/Year) 3. Title and Amount of Securities Underlying Derivative Security (Instr. 4) 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 6. Nature of Indirect Beneficial Ownership (Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Explanation of Responses:
See Exhibit 24 - Power of Attorney
/s/ Ryan Brown, as Attorney-in-Fact for Michael Andrew Chambers 06/06/2022
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

       KNOW ALL BY THESE PRESENTS, that the undersigned hereby constitutes and
Douglas S. Ingram and Ryan E. Brown, and their respective successors, and each
of them his true and
lawful attorney-in-fact and agent with full power of substitution, signing
singly, for his and in his name,
place and stead, in any and all capacities, to:

1.	complete and execute for and on behalf of the undersigned, in the
undersigned's capacity as an
officer and/or director of Sarepta Therapeutics, Inc. (the "Company") and/or 10%
holder of the
Company's capital stock, Forms 3, 4, 5 and Form ID, any other forms, and any
thereto in accordance with Section 16(a) of the Exchange Act and the rules and

2.	do and perform any and all acts for and on behalf of the undersigned which
may be necessary or
desirable to complete and execute any such Form 3, 4, 5 or Form ID, or any other
complete and execute any amendment or amendments thereto, and timely file such
form with the
SEC and any stock exchange or similar authority; and

3.	take any other action of any type whatsoever in connection with the foregoing
which, in the
opinion of such attorney-in-fact, may be of benefit to, in the best interest of,
or legally required
by, the undersigned, it being understood that the documents executed by such
attorney-in-fact on
behalf of the undersigned pursuant to this Power of Attorney shall be in such
form and shall
contain such terms and conditions as such attorney-in-fact may approve in such

       The undersigned hereby grants to each such attorney-in-fact full power
and authority to do and
perform any and every act and thing whatsoever requisite, necessary or proper to
be done in the exercise
of any of the rights and powers herein granted, as fully to all intents and
purposes as the undersigned
might or could do if personally present, with full power of substitution or
revocation, hereby ratifying and
confirming all that such attorney-in-fact, or such attorney-in-fact's substitute
or substitutes, shall lawfully
do or cause to be done by virtue of this power of attorney and the rights and
powers herein granted. The
undersigned acknowledges that the foregoing attorneys-in-fact, in serving in
such capacity at the request
of the undersigned, are not assuming, nor is the Company assuming, any of the
responsibilities to comply with Section 16 of the Exchange Act.

       The undersigned agrees that each such attorney-in-fact herein may rely
entirely on information
furnished orally or in writing by the undersigned to such attorney-in-fact. The
undersigned also agrees to
indemnify and hold harmless the Company and each such attorney-in-fact against
any losses, claims,
damages or liabilities (or actions in these respects) that arise out of or are
based upon any untrue
statements or omission of necessary facts in the information provided by the
undersigned to such
attorney-in fact for purposes of executing, acknowledging, delivering or filing
Forms 3, 4 or 5, Form ID
or any other form (including amendments thereto) and agrees to reimburse the
Company and such
attorney-in-fact for any legal or other expenses reasonably incurred in
connection with investigating or
defending against any such loss, claim, damage, liability or action.

       This Power of Attorney supersedes any power of attorney previously
executed by the undersigned
regarding the purposes outlined in the first paragraph hereof ("Prior Powers of
Attorney"), and the
authority of the attorneys-in-fact named in any Prior Powers of Attorney is
hereby revoked.

       This Power of Attorney shall remain in full force and effect until the
undersigned is no longer
required to file Forms 3, 4 and 5 with respect to the undersigned's holdings of
and transactions in
securities issued by the Company, unless earlier (a) revoked by the undersigned
in a signed writing
delivered to the foregoing attorneys-in-fact or (b) superseded by a new power of
attorney regarding the
purposes outlined in the first paragraph hereof dated as of a later date.

       IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to
be executed as
of this day of 25 May, 2022.

Signature: /s/ Michael Chambers

Michael Chambers