00000 - Document - Template Link link:presentationLink link:calculationLink link:definitionLink 100000 - Document - Document and Entity Information link:calculationLink link:presentationLink link:definitionLink 100010 - Statement - Consolidated Balance Sheets link:calculationLink link:presentationLink link:definitionLink 100020 - Statement - Consolidated Balance Sheets (Parenthetical) link:calculationLink link:presentationLink link:definitionLink 100030 - Statement - Consolidated Statements of Operations and Comprehensive Loss link:calculationLink link:presentationLink link:definitionLink 100040 - Statement - Consolidated Statements of Stockholders' Equity link:calculationLink link:presentationLink link:definitionLink 100050 - Statement - Consolidated Statements of Cash Flows link:calculationLink link:presentationLink link:definitionLink 100060 - Disclosure - ORGANIZATION AND NATURE OF BUSINESS link:calculationLink link:presentationLink link:definitionLink 100070 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES AND RECENT ACCOUNTING PRONOUNCEMENTS link:calculationLink link:presentationLink link:definitionLink 100080 - Disclosure - SIGNIFICANT AGREEMENTS link:calculationLink link:presentationLink link:definitionLink 100090 - Disclosure - FAIR VALUE MEASUREMENTS link:calculationLink link:presentationLink link:definitionLink 100100 - Disclosure - CASH, CASH EQUIVALENTS AND SHORT-TERM INVESTMENTS link:calculationLink link:presentationLink link:definitionLink 100110 - Disclosure - OTHER CURRENT ASSETS link:calculationLink link:presentationLink link:definitionLink 100120 - Disclosure - PROPERTY AND EQUIPMENT link:calculationLink link:presentationLink link:definitionLink 100130 - Disclosure - ACCRUED EXPENSES link:calculationLink link:presentationLink link:definitionLink 100140 - Disclosure - INDEBTEDNESS link:calculationLink link:presentationLink link:definitionLink 100150 - Disclosure - EQUITY FINANCING link:calculationLink link:presentationLink link:definitionLink 100160 - Disclosure - STOCK-BASED COMPENSATION link:calculationLink link:presentationLink link:definitionLink 100170 - Disclosure - 401 (K) PLAN link:calculationLink link:presentationLink link:definitionLink 100180 - Disclosure - INCOME TAXES link:calculationLink link:presentationLink link:definitionLink 100190 - Disclosure - NET LOSS PER SHARE link:calculationLink link:presentationLink link:definitionLink 100200 - Disclosure - COMMITMENTS AND CONTINGENCIES link:calculationLink link:presentationLink link:definitionLink 100210 - Disclosure - FINANCIAL INFORMATION BY QUARTER (UNAUDITED) link:calculationLink link:presentationLink link:definitionLink 100220 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES AND RECENT ACCOUNTING PRONOUNCEMENTS (Policies) link:calculationLink link:presentationLink link:definitionLink 100230 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES AND RECENT ACCOUNTING PRONOUNCEMENTS (Tables) link:calculationLink link:presentationLink link:definitionLink 100240 - Disclosure - FAIR VALUE MEASUREMENTS (Tables) link:calculationLink link:presentationLink link:definitionLink 100250 - Disclosure - CASH, CASH EQUIVALENTS AND SHORT-TERM INVESTMENTS (Tables) link:calculationLink link:presentationLink link:definitionLink 100260 - Disclosure - OTHER CURRENT ASSETS (Tables) link:calculationLink link:presentationLink link:definitionLink 100270 - Disclosure - PROPERTY AND EQUIPMENT (Tables) link:calculationLink link:presentationLink link:definitionLink 100280 - Disclosure - ACCRUED EXPENSES (Tables) link:calculationLink link:presentationLink link:definitionLink 100290 - Disclosure - INDEBTEDNESS (Tables) link:calculationLink link:presentationLink link:definitionLink 100300 - Disclosure - STOCK-BASED COMPENSATION (Tables) link:calculationLink link:presentationLink link:definitionLink 100310 - Disclosure - INCOME TAXES (Tables) link:calculationLink link:presentationLink link:definitionLink 100320 - Disclosure - NET LOSS PER SHARE (Tables) link:calculationLink link:presentationLink link:definitionLink 100330 - Disclosure - COMMITMENTS AND CONTINGENCIES (Tables) link:calculationLink link:presentationLink link:definitionLink 100340 - Disclosure - FINANCIAL INFORMATION BY QUARTER (UNAUDITED) (Tables) link:calculationLink link:presentationLink link:definitionLink 100350 - Disclosure - Organization and Nature of Business - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100360 - Disclosure - Summary of Significant Accounting Policies and Recent Accounting Pronouncements - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100370 - Disclosure - Summary of Estimated Useful Lives of Plant and Equipment (Detail) link:calculationLink link:presentationLink link:definitionLink 100380 - Disclosure - Summary of Estimated Future Amortization for Patent Costs (Detail) link:calculationLink link:presentationLink link:definitionLink 100390 - Disclosure - Significant Agreements - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100400 - Disclosure - Assets Measured and Carried at Fair Value (Detail) link:calculationLink link:presentationLink link:definitionLink 100410 - Disclosure - Cash, Cash Equivalents and Short-Term Investments - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100420 - Disclosure - Summary of Company Cash, Cash Equivalents and Short-term Investments (Detail) link:calculationLink link:presentationLink link:definitionLink 100430 - Disclosure - Summary of Other Current Assets (Detail) link:calculationLink link:presentationLink link:definitionLink 100440 - Disclosure - Summarizes Components of Property and Equipment, Net (Detail) link:calculationLink link:presentationLink link:definitionLink 100450 - Disclosure - Property and Equipment - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100460 - Disclosure - Summary of Accrued Expenses (Detail) link:calculationLink link:presentationLink link:definitionLink 100470 - Disclosure - Indebtedness - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100480 - Disclosure - Indebtedness - Components of Long-Term Debt (Detail) link:calculationLink link:presentationLink link:definitionLink 100490 - Disclosure - Indebtedness - Summarizes Total Payments under Company's Debt Arrangements (Detail) link:calculationLink link:presentationLink link:definitionLink 100500 - Disclosure - Equity Financing - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100510 - Disclosure - Stock Based Compensation - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100520 - Disclosure - Assumptions for Measuring Fair Values of Stocks (Detail) link:calculationLink link:presentationLink link:definitionLink 100530 - Disclosure - Assumptions for Measuring Fair Values of Stocks (Parenthetical) (Detail) link:calculationLink link:presentationLink link:definitionLink 100540 - Disclosure - Summary of Stock Option Activity (Detail) link:calculationLink link:presentationLink link:definitionLink 100550 - Disclosure - Summary of Company's Stock Options Vested and Exercised (Detail) link:calculationLink link:presentationLink link:definitionLink 100560 - Disclosure - Summary of Restricted Stock Award Activity (Detail) link:calculationLink link:presentationLink link:definitionLink 100570 - Disclosure - Summary of Stock Appreciation Rights Activity (Detail) link:calculationLink link:presentationLink link:definitionLink 100580 - Disclosure - Summary of Employee Stock Purchase Plan Activity and Expense (Detail) link:calculationLink link:presentationLink link:definitionLink 100590 - Disclosure - Summary of Stock-Based Compensation Expense by Function Included within Consolidated Statement of Operations and Comprehensive Loss (Detail) link:calculationLink link:presentationLink link:definitionLink 100600 - Disclosure - Summary of Stock-Based Compensation Expense by Grant Type Included within Consolidated Statement of Operations and Comprehensive Loss (Detail) link:calculationLink link:presentationLink link:definitionLink 100610 - Disclosure - 401 (K) PLAN - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100620 - Disclosure - Income Taxes - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100630 - Disclosure - Analysis of Deferred Tax Assets (Detail) link:calculationLink link:presentationLink link:definitionLink 100640 - Disclosure - Reconciliation Between Effective Tax Rate and Income Tax Rate (Detail) link:calculationLink link:presentationLink link:definitionLink 100650 - Disclosure - Reconciliation of Beginning and Ending Amount of Unrecognized Tax Benefits (Detail) link:calculationLink link:presentationLink link:definitionLink 100660 - Disclosure - Basic and Diluted Net Loss Per Share (Detail) link:calculationLink link:presentationLink link:definitionLink 100670 - Disclosure - Basic and Diluted Net Loss Per Share (Parenthetical) (Detail) link:calculationLink link:presentationLink link:definitionLink 100680 - Disclosure - Commitments and Contingencies - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100690 - Disclosure - Summary of Aggregate Non-Cancelable Future Minimum Payments under Company's Leases (Detail) link:calculationLink link:presentationLink link:definitionLink 100700 - Disclosure - Non-Cancelable Contractual Obligations (Detail) link:calculationLink link:presentationLink link:definitionLink 100710 - Disclosure - Financial Information by Quarter (Detail) link:calculationLink link:presentationLink link:definitionLink