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  <xsd:element id="srpt_BioMarinPharmaceuticalIncorporationMember" name="BioMarinPharmaceuticalIncorporationMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="srpt_CashCashEquivalentsAndInvestments" name="CashCashEquivalentsAndInvestments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="srpt_ManufacturingRelatedDepositsAndPrepaidExpenseCurrent" name="ManufacturingRelatedDepositsAndPrepaidExpenseCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="srpt_OtherAccrualsMember" name="OtherAccrualsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="srpt_UpFrontAndDevelopmentMilestoneExpenses" name="UpFrontAndDevelopmentMilestoneExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="srpt_CommonStockPurchased" name="CommonStockPurchased" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="srpt_AvailableForSaleDebtSecuritiesCurrentAccumulatedGrossUnrealizedLossBeforeTax" name="AvailableForSaleDebtSecuritiesCurrentAccumulatedGrossUnrealizedLossBeforeTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="srpt_RebatesMember" name="RebatesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="srpt_SummaryOfChangeInReservesForDiscountsAndAllowancesTableTextBlock" name="SummaryOfChangeInReservesForDiscountsAndAllowancesTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="srpt_CollaborationReceivable" name="CollaborationReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="srpt_WeightedAverageMaturityPeriodOfAvailableForSaleSecurities" name="WeightedAverageMaturityPeriodOfAvailableForSaleSecurities" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="srpt_CashDepositsAndMoneyMarketFundsMember" name="CashDepositsAndMoneyMarketFundsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="srpt_ReductionToRightOfUseAssetsAndLeaseLiabilities" name="ReductionToRightOfUseAssetsAndLeaseLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="srpt_LacertaTherapeuticsIncMember" name="LacertaTherapeuticsIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="srpt_CatalentAndThermoMember" name="CatalentAndThermoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="srpt_FairValueConvertibleNoteExchange" name="FairValueConvertibleNoteExchange" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="srpt_InducementExpenseRelatedToDebt" name="InducementExpenseRelatedToDebt" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="srpt_PrepaidMaintenanceServicesCurrent" name="PrepaidMaintenanceServicesCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="srpt_AccruedClinicalAndPreclinicalCostsCurrent" name="AccruedClinicalAndPreclinicalCostsCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="srpt_CustomerThreeMember" name="CustomerThreeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="srpt_ResearchOptionAndMilestoneExpense" name="ResearchOptionAndMilestoneExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="srpt_SublicensePayment" name="SublicensePayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="srpt_EquityInvestmentPubliclyTradedSecurity" name="EquityInvestmentPubliclyTradedSecurity" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="srpt_DeferredRevenueSeparateMaterialOptionsRight" name="DeferredRevenueSeparateMaterialOptionsRight" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="srpt_UnrealizedGainsLossesOnInvestmentsNetOfTax" name="UnrealizedGainsLossesOnInvestmentsNetOfTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="srpt_CollaborationReceivableCurrent" name="CollaborationReceivableCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="srpt_GainFromSaleOfIntangibleAssetTable" name="GainFromSaleOfIntangibleAssetTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="srpt_PrepaidResearchExpensesCurrent" name="PrepaidResearchExpensesCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="srpt_SummaryOfSignificantAccountingPoliciesTable" name="SummaryOfSignificantAccountingPoliciesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="srpt_CustomerTwoMember" name="CustomerTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="srpt_FirstInstallmentsMember" name="FirstInstallmentsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="srpt_SummaryOfReservesForDiscountsAndAllowancesIncludedInConsolidatedBalanceSheetsTableTextBlock" name="SummaryOfReservesForDiscountsAndAllowancesIncludedInConsolidatedBalanceSheetsTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="srpt_RemainingSharesAssociatedWithPerformanceCondition" name="RemainingSharesAssociatedWithPerformanceCondition" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="srpt_TwoThousandAndTwentySevenSeniorConvertibleNotesMember" name="TwoThousandAndTwentySevenSeniorConvertibleNotesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="srpt_AccruedProductRevenueRelatedReserveCurrent" name="AccruedProductRevenueRelatedReserveCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="srpt_DevelopmentRegulatoryAndSalesMilestonePaymentsToBePaid" name="DevelopmentRegulatoryAndSalesMilestonePaymentsToBePaid" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="srpt_HenogenSaMember" name="HenogenSaMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="srpt_GainLossOnContingentConsiderationNet" name="GainLossOnContingentConsiderationNet" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="srpt_AvailableForSaleDebtSecuritiesCurrentAmortizedCostBasis" name="AvailableForSaleDebtSecuritiesCurrentAmortizedCostBasis" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="srpt_GainFromSaleOfIntangibleAssetLineItems" name="GainFromSaleOfIntangibleAssetLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="srpt_PrepaidClinicalAndPreclinicalExpensesCurrent" name="PrepaidClinicalAndPreclinicalExpensesCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="srpt_AccruedCollaborationCostSharing" name="AccruedCollaborationCostSharing" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="srpt_RemainingExpenseAssociatedInShare" name="RemainingExpenseAssociatedInShare" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="srpt_PartialSettlementOfCappedCallShareOptionsFor2024Notes" name="PartialSettlementOfCappedCallShareOptionsFor2024Notes" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="srpt_TwoThousandTwentyFourNotesInducedConversionMember" name="TwoThousandTwentyFourNotesInducedConversionMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="srpt_SeptemberTwentyTwoThousandTwentyFiveMember" name="SeptemberTwentyTwoThousandTwentyFiveMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="srpt_CashCashEquivalentsAndInvestmentsAmortizedCostBasis" name="CashCashEquivalentsAndInvestmentsAmortizedCostBasis" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="srpt_ManufacturingRelatedDepositsAndPrepaidExpenseNonCurrent" name="ManufacturingRelatedDepositsAndPrepaidExpenseNonCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="srpt_LetterOfCreditReduce" name="LetterOfCreditReduce" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="srpt_SummaryOfSignificantAccountingPoliciesLineItems" name="SummaryOfSignificantAccountingPoliciesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="srpt_RocheMember" name="RocheMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="srpt_AdjustmentsToProductRevenueReservesRelatingToSalesInPriorYears" name="AdjustmentsToProductRevenueReservesRelatingToSalesInPriorYears" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="srpt_ReservesForReductionToAccountsReceivable" name="ReservesForReductionToAccountsReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="srpt_NoAdditionalMilestonePaymentToBePaidByCompany" name="NoAdditionalMilestonePaymentToBePaidByCompany" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="srpt_ManufacturingCommitmentsAgreementMember" name="ManufacturingCommitmentsAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="srpt_CommitmentsAndContingenciesTable" name="CommitmentsAndContingenciesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="srpt_EmployeeStockPurchasePlanMember" name="EmployeeStockPurchasePlanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="srpt_TwoThousandAndNineteenTermLoanMember" name="TwoThousandAndNineteenTermLoanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="srpt_ConvertibleDebtAndTermLoanAndRevolverAndMortgageLoansMember" name="ConvertibleDebtAndTermLoanAndRevolverAndMortgageLoansMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="srpt_StrategicEquityInvestmentsMember" name="StrategicEquityInvestmentsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="srpt_SignificantAccountingPoliciesPolicyTextBlock" name="SignificantAccountingPoliciesPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="srpt_PaymentsCreditsReservesForDiscountsAndAllowances" name="PaymentsCreditsReservesForDiscountsAndAllowances" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="srpt_AvailableForSaleDebtSecuritiesCurrentAccumulatedGrossUnrealizedGainBeforeTax" name="AvailableForSaleDebtSecuritiesCurrentAccumulatedGrossUnrealizedGainBeforeTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="srpt_GainLossFromSaleOfIntangibleAssetsDisclosureTextBlock" name="GainLossFromSaleOfIntangibleAssetsDisclosureTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="srpt_AccruedSponsoredResearchAgreements" name="AccruedSponsoredResearchAgreements" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="srpt_AllocatedShareBasedCompensationExpenses" name="AllocatedShareBasedCompensationExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="srpt_ObligationsDueToDevelopmentRegulatoryCommercialMilestoneAndUpFrontRoyaltyPayments" name="ObligationsDueToDevelopmentRegulatoryCommercialMilestoneAndUpFrontRoyaltyPayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="srpt_IncreaseDecreaseInConvertibleNotes" name="IncreaseDecreaseInConvertibleNotes" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="srpt_ReductionInTheCarryingAmountsOfTheRightOfUseAssets" name="ReductionInTheCarryingAmountsOfTheRightOfUseAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="srpt_CashCashEquivalentsAndInvestmentsGrossUnrealizedGainBeforeTax" name="CashCashEquivalentsAndInvestmentsGrossUnrealizedGainBeforeTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="srpt_ReservesForComponentOfAccruedExpenses" name="ReservesForComponentOfAccruedExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="srpt_ContractualObligationToBePaidAfterYearFour" name="ContractualObligationToBePaidAfterYearFour" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="srpt_NationwideChildrensHospitalMember" name="NationwideChildrensHospitalMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="srpt_ProvisionForReservesForDiscountsAndAllowances" name="ProvisionForReservesForDiscountsAndAllowances" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="srpt_InventoryCurrentAndNoncurrentNet" name="InventoryCurrentAndNoncurrentNet" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="srpt_Summaryofinventorybalancesheetclassificationtabletextblock" name="Summaryofinventorybalancesheetclassificationtabletextblock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="srpt_OtherNonoperatingExpenses" name="OtherNonoperatingExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="srpt_IncreaseDecreaseInAdditionalPaidInCapital" name="IncreaseDecreaseInAdditionalPaidInCapital" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="srpt_PromptPayMember" name="PromptPayMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="srpt_AccruedFixedAssets" name="AccruedFixedAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="srpt_LongTermDebtMaturitiesRepaymentsOfPrincipalAfterYearFour" name="LongTermDebtMaturitiesRepaymentsOfPrincipalAfterYearFour" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="srpt_InstallmentsDateOfImplementedFee" name="InstallmentsDateOfImplementedFee" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="srpt_AccountsReceivablePaymentTerms" name="AccountsReceivablePaymentTerms" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="srpt_AccountsReceivablePaymentTerm" name="AccountsReceivablePaymentTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="srpt_NationwideChildrenHospitalMember" name="NationwideChildrenHospitalMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="srpt_ProceedsFromSaleOfRarePediatricDiseasePriorityReviewVoucherNetOfCommission" name="ProceedsFromSaleOfRarePediatricDiseasePriorityReviewVoucherNetOfCommission" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="srpt_IncreaseDecreaseInAccumulatedDeficit" name="IncreaseDecreaseInAccumulatedDeficit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="srpt_RestrictedStockAndRestrictedStockUnitsRSUsMember" name="RestrictedStockAndRestrictedStockUnitsRSUsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="srpt_TwoThousandSeventeenCappedCallsPartialSettlementMember" name="TwoThousandSeventeenCappedCallsPartialSettlementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="srpt_MilestonePaymentToBePaidByCompanyUponSpecifiedResearchMilestoneAchievement" name="MilestonePaymentToBePaidByCompanyUponSpecifiedResearchMilestoneAchievement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="srpt_CappedCallTransactionsMember" name="CappedCallTransactionsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="srpt_TwoThousandSeventeenCappedCallTransactionsMember" name="TwoThousandSeventeenCappedCallTransactionsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="srpt_OtherInvestingActivity" name="OtherInvestingActivity" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="srpt_ColumbusOhioMember" name="ColumbusOhioMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="srpt_DebtConversionCosts" name="DebtConversionCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="srpt_StrategicInvestmentsNoncurrent" name="StrategicInvestmentsNoncurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="srpt_AccruedContractManufacturingExpenseCurrent" name="AccruedContractManufacturingExpenseCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
</xsd:schema>
