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10-K true 2021-12-31 --12-31 2021 false 001-14895 Sarepta Therapeutics, Inc. DE 93-0797222 215 First Street Suite 415 Cambridge MA 02142 617 274-4000 Common Stock, $0.0001 par value SRPT NASDAQ Yes No Yes Yes Large Accelerated Filer false false false false 6206016151 87149589 The registrant has incorporated by reference into Part II and Part III of this Annual Report on Form 10-K portions of its definitive Proxy Statement for the 2022 Annual Meeting of Stockholders to be filed no later than 120 days after the end of the fiscal year covered by this Annual Report on Form 10-K. 185 KPMG LLP Boston, Massachusetts

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Basis of PresentationThe accompanying consolidated financial statements, which have been prepared in accordance with accounting principles generally accepted in the U.S. (“U.S. GAAP”), reflect the accounts of Sarepta Therapeutics, Inc. and its wholly-owned subsidiaries. All intercompany transactions between and among its consolidated subsidiaries have been eliminated. Management has determined that the Company operates in one segment: discovering, developing, manufacturing and delivering therapies to patients with rare diseases. The Company’s CEO, as the chief operating decision-maker, manages and allocates resources to the operations of the Company on a total company basis. The Company’s research and development organization is responsible for the research and discovery of new product candidates and supports development and registration efforts for potential future products. The Company’s supply chain organization manages the development of the manufacturing processes, clinical trial supply and commercial product supply. The Company’s commercial organization is responsible for commercialization of EXONDYS 51, VYONDYS 53 and AMONDYS 45 in the U.S. and internationally. The Company is supported by other back-office general and administration functions. Consistent with this decision-making process, the Company’s CEO uses consolidated, single-segment financial information for purposes of evaluating performance, forecasting future period financial results, allocating resources and setting incentive targets. In the opinion of the Company’s management, all adjustments of a normal recurring nature necessary for a fair presentation have been reflected.

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Property and EquipmentProperty and equipment are initially recorded at cost, including the acquisition cost and all costs necessarily incurred to bring the asset to the location and working condition necessary for their intended use. The cost of normal, recurring or periodic repairs and maintenance activities related to property and equipment are expensed as incurred. The cost for planned major maintenance activities, including the related acquisition or construction of assets, is capitalized if the repair will result in future economic benefits. Interest costs incurred during the construction period of major capital projects are periodically reviewed, and if determined to be material, capitalized until the asset is ready for its intended use, at which point the interest costs are amortized as depreciation expense over the life of the underlying asset. <div style="font-size:13.5pt;font-family:Times New Roman;">The Company generally depreciates the cost of its property and equipment using the straight-line method over the estimated useful lives of the respective assets, which are summarized as follows: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:60.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:46.543%;"/> <td style="width:3.457%;"/> <td style="width:50.0%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Asset Category</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Useful lives</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:middle;">Lab and manufacturing equipment</td> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">5 years</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:middle;">Office equipment</td> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">5 years</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:top;">Software and computer equipment</td> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">3 - 5 years</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:middle;">Furniture and fixtures</td> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">7 years</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:middle;">Leasehold improvements</td> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Lesser of the useful life or the term of the respective lease</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:middle;">Land improvements</td> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">25 years</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:middle;">Land</td> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Not depreciated</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:middle;">Building and improvements</td> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">30 years</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:top;">Construction in progress</td> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Not depreciated until put into service</td> </tr> </table> </div>

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Intangible assetsThe Company’s intangible assets consist of in-licensed rights, patent costs and software licenses, which are stated in the Company’s consolidated balance sheets, net of accumulated amortization and impairments, if applicable. The in-licensed rights primarily relate to agreements with BioMarin Pharmaceutical, Inc. (“BioMarin”) and the University of Western Australia (“UWA”). The in-licensed rights are being amortized on a straight-line basis over the remaining life of the related patents because the life of the related patents reflects the expected time period that the Company will benefit from the in-licensed rights. Patent costs consist primarily of external legal costs, filing fees incurred to file patent applications and renewal fees on proprietary technology developed or licensed by the Company. Patent costs associated with applying for a patent, being issued a patent and annual renewal fees are capitalized. Costs to defend a patent and costs to invalidate a competitor’s patent or patent application are expensed as incurred. Patent costs are amortized on a straight-line basis over the shorter of the estimated economic lives or the initial term of the patents, which is generally 20 years.

P20Y

Revenue Recognition The Company recognizes revenue when a customer obtains control of promised goods or services, in an amount that reflects the consideration which the Company expects to receive in exchange for the goods or services provided. To determine revenue recognition for arrangements within the scope of ASC Topic 606, Revenue from Contracts with Customers (“ASC 606”), the Company performs the following five steps: (1) identify the contract with the customer; (2) identify the performance obligations in the contract; (3) determine the transaction price; (4) allocate the transaction price to the performance obligations in the contract; and (5) recognize revenue when or as the Company satisfies a performance obligation. The Company only applies the five-step model to contracts when it is probable that the entity will collect the consideration it is entitled to in exchange for the goods or services it transfers or provides to the customer. At contract inception, the Company assesses the goods or services promised within each contract and determines those that are performance obligations, and assesses whether each promised good or service is distinct. The Company then recognizes as revenue the amount of the transaction price that is allocated to the respective performance obligation when or as the performance obligation is satisfied. The only performance obligation in the Company’s contracts with customers is to timely deliver drug products to the customer’s designated location.Product revenuesThe Company distributes its products principally through its customers. The customers subsequently resell the products to patients and health care providers. The Company provides no right of return to the customers except in cases of shipping error or product defect. Product revenues are recognized when the customers take control of the products, which typically occurs upon delivery to the customers. For the years ended December 31, 2021, 2020 and 2019, the majority of the product revenues recognized were generated by the specialty distributor and specialty pharmacies in the U.S.Variable ConsiderationProduct revenues are recorded at the net sales price (transaction price) which includes estimated reserves for variable consideration, such as Medicaid rebates, governmental chargebacks, including PHS chargebacks, prompt payment discounts, co-pay assistance and distribution fees. These reserves reflect the Company’s best estimates of the amount of consideration to which it is entitled based on the terms of the contracts. Additional details relating to variable consideration follows:<div style="margin-left:6.667%;display:flex;margin-top:6.0pt;line-height:1.15;justify-content:flex-start;align-items:baseline;margin-bottom:0.0pt;min-width:4.537%;text-align:left;"><span style="background-color:rgba(0,0,0,0);color:rgba(0,0,0,1);white-space:pre-wrap;font-weight:normal;font-size:10.0pt;font-family:Times New Roman;display:inline-flex;font-size:10.0pt;font-family:Times New Roman;justify-content:flex-start;min-width:4.86108878960282%;">•<div style="display:inline;">Medicaid rebates relate to the Company’s estimated obligations to states under established reimbursement arrangements. Medicaid rebate reserves are recorded in the same period the related revenue is recognized, resulting in a reduction of product revenue and the establishment of a liability which is included in accrued expenses.</div></div><div style="margin-left:6.667%;display:flex;margin-top:6.0pt;line-height:1.15;justify-content:flex-start;align-items:baseline;margin-bottom:0.0pt;min-width:4.537%;text-align:left;"><span style="background-color:rgba(0,0,0,0);color:rgba(0,0,0,1);white-space:pre-wrap;font-weight:normal;font-size:10.0pt;font-family:Times New Roman;display:inline-flex;font-size:10.0pt;font-family:Times New Roman;justify-content:flex-start;min-width:4.86108878960282%;">•<div style="display:inline;">Governmental chargebacks, including PHS chargebacks, relate to the Company’s estimated obligations resulting from contractual commitments to sell products to qualified healthcare providers at prices lower than the list prices that the Company charges to wholesalers. The wholesaler charges the Company for the difference between what the wholesaler pays for the products and the ultimate selling price to the qualified healthcare providers. Chargeback reserves are recorded in the same period the related revenue is recognized, resulting in a reduction of product revenue and accounts receivable. Chargeback amounts are generally determined at the time of resale to the qualified healthcare provider from the wholesaler, and the Company generally issues credits for such amounts within a few weeks of receiving notification of resale from the wholesaler.</div></div><div style="margin-left:6.667%;display:flex;margin-top:6.0pt;line-height:1.15;justify-content:flex-start;align-items:baseline;margin-bottom:0.0pt;min-width:4.537%;text-align:left;"><span style="background-color:rgba(0,0,0,0);color:rgba(0,0,0,1);white-space:pre-wrap;font-weight:normal;font-size:10.0pt;font-family:Times New Roman;display:inline-flex;font-size:10.0pt;font-family:Times New Roman;justify-content:flex-start;min-width:4.86108878960282%;">•<div style="display:inline;">Prompt payment discounts relate to the Company’s estimated obligations for credits to be granted to specialty pharmacies for remitting payment on their purchases within established incentive periods. Reserves for prompt payment discounts are recorded in the same period the related revenue is recognized, resulting in a reduction of product revenue and accounts receivable.</div></div><div style="margin-left:6.667%;display:flex;margin-top:6.0pt;line-height:1.15;justify-content:flex-start;align-items:baseline;margin-bottom:0.0pt;min-width:4.537%;text-align:left;"><span style="background-color:rgba(0,0,0,0);color:rgba(0,0,0,1);white-space:pre-wrap;font-weight:normal;font-size:10.0pt;font-family:Times New Roman;display:inline-flex;font-size:10.0pt;font-family:Times New Roman;justify-content:flex-start;min-width:4.86108878960282%;">•<div style="display:inline;">Co-pay assistance relates to financial assistance provided to qualified patients, whereby the Company may assist them with prescription drug co-payments required by the patient’s insurance provider. Reserves for co-pay assistance are recorded in the same period the related revenue is recognized, resulting in a reduction of product revenue and the establishment of a liability which is included in accrued expenses.</div></div><div style="margin-left:6.667%;display:flex;margin-top:6.0pt;line-height:1.15;justify-content:flex-start;align-items:baseline;margin-bottom:0.0pt;min-width:4.537%;text-align:left;"><span style="background-color:rgba(0,0,0,0);color:rgba(0,0,0,1);white-space:pre-wrap;font-weight:normal;font-size:10.0pt;font-family:Times New Roman;display:inline-flex;font-size:10.0pt;font-family:Times New Roman;justify-content:flex-start;min-width:4.86108878960282%;">•<div style="display:inline;">Distribution fees relate to fees paid to customers in the distribution channel that provide the Company with inventory management, data and distribution services and are generally accounted for as a reduction of revenue. To the extent that the services received are distinct from the Company’s sale of products to the customers, these payments are accounted for as selling, general and administrative expenses. Reserves for distribution fees result in an increase in a liability if payments are required of the Company or a reduction of accounts receivable if no payments are required of the Company. </div></div>Collaboration revenueThe Company’s collaboration revenue is primarily generated from its collaboration arrangement with F. Hoffman-La Roche Ltd. (“Roche”). For more information, please read Note 3, Collaboration and License Agreements. At the inception of a collaboration arrangement, the Company first assesses whether the contractual arrangement is within the scope of ASC Topic 808, Collaborative Arrangements (“ASC 808”) to determine whether the arrangement involves a joint operating activity and involves two (or more) parties that are both active participants in the activity and exposed to significant risks and rewards dependent on the commercial success of such activity. Then the Company determines whether the collaboration arrangement in its entirety represents a contract with a customer as defined by ASC 606. If only a portion of the collaboration arrangement is potentially with a customer, the Company applies the distinct good or service unit-of-account guidance in ASC 606 to determine whether there is a unit of account that should be accounted for under ASC 606. For the units of account in the collaboration arrangement that do not represent a vendor-customer relationship, the Company will (i) consider applying other GAAP, including by analogy, or (ii) if there is no appropriate analogy, consistently apply a reasonable and rational accounting policy election. In general, by analogy to ASC 606, the Company identifies the performance obligations within the collaboration arrangement and identifies and allocates the transaction price the Company expects to receive on a relative standalone selling price basis to each performance obligation. Variable consideration, consisting of development and regulatory milestones, will be included in the transaction price only if the Company expects to receive such consideration and if it is probable that the inclusion of the variable consideration will not result in a significant reversal in the cumulative amount of revenue recognized under the arrangement. Sales-based royalty and milestone payments are excluded from the transaction price the Company expects to receive until the underlying sales occur because the license to the Company’s intellectual property is deemed to be the predominant item to which the royalties or milestones relate as it is the primary driver of value in its collaboration arrangement. For the recognition of revenue associated with each performance obligation, if the Company determines ASC 606 is not appropriate to apply by analogy, the Company will apply a reasonable, rational and consistently applied accounting policy election to faithfully depict the transfer of services to the collaboration partner over the estimated performance period. Up-front payments from a collaboration partner are recognized as deferred revenue when received and recognized as revenue over the estimated performance period. Reimbursement payments from a collaboration partner associated with cost sharing provisions in a collaboration arrangement are recognized as the related expense is incurred and classified as an offset to operating expenses.

Valuation of Product OptionsThe Company's collaboration arrangements may contain options which provide the collaboration partner with the right to obtain additional licenses. If an arrangement contains product options, by analogy to ASC 606, the Company evaluates the product options to determine whether they represent material rights, which may include options to acquire additional goods or services for free or at a discount. If the customer options are determined to represent material rights, they are recognized as a separate performance obligation at inception of the arrangement. The Company allocates a portion of the transaction price of the collaboration arrangement to material rights based on the relative standalone selling price. Amounts allocated to material rights are not recognized as revenue until related options are exercised or expire. Key assumptions to determine the standalone selling price of product options in a collaboration arrangement include, but are not limited to, forecasted revenues, development timelines, incremental costs related to the arrangement, discount rates and likelihood of technical and regulatory success.

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Contingent Consideration Certain of the Company’s license and collaboration agreements include future payments that are contingent upon the receipt, or receipt and subsequent sale, of a Priority Review Voucher (“PRV”). The Company has concluded that these contingent payments represent embedded derivatives. The Company records a liability for such contingent payments at fair value on the date the agreements are effective. The Company estimates the fair value of contingent consideration derivatives through a valuation model that includes an income approach based on the probability-weighted expected cash flows that incorporated industry-based probability adjusted assumptions relating to the achievement of the milestone and thus the likelihood of making the payments. Changes in the fair value of the contingent consideration derivatives can result from changes to one or multiple assumptions, including adjustments to the discount rates, the assumed development timeline and the probability of achievement of certain regulatory milestones. The Company revalues its contingent consideration derivatives upon a material change to one or more of the assumptions discussed above. Changes in the fair value of the Company’s contingent consideration derivatives are recognized in the Company’s consolidated statements of operations and comprehensive loss. Such changes are classified as other income (loss) which corresponds to the classification of any gain recognized upon the actual sale of a PRV.

Recent Accounting PronouncementsRecently adoptedIn August 2020, the Financial Accounting Standards Board (“FASB”) issued ASU 2020-06, “Debt - Debt with Conversion and Other Options (Subtopic 470-20) and Derivatives and Hedging - Contracts in Entity's Own Equity (Subtopic 815-40): Accounting for Convertible Instruments and Contracts in an Entity's Own Equity.” This ASU simplifies the complexity associated with applying U.S. GAAP for certain financial instruments with characteristics of liabilities and equity. More specifically, the amendments focus on the guidance for convertible instruments and derivative scope exceptions for contracts in an entity’s own equity. Under ASU 2020-06, the embedded conversion features are no longer separated from the host contract for convertible instruments with conversion features that are not required to be accounted for as derivatives under ASC 815, or that do not result in substantial premiums accounted for as paid-in capital. Consequently, a convertible debt instrument, such as the Company’s senior notes due on November 15, 2024 (the “2024 Notes”), will be accounted for as a single liability measured at its amortized cost, as long as no other features require bifurcation and recognition as derivatives. The new guidance also requires the if-converted method to be applied for all convertible instruments and requires additional disclosures. This guidance is required to be adopted by January 1, 2022, and early adoption is permitted, but no earlier than fiscal years beginning after December 15, 2020. The Company elected to early adopt this guidance on January 1, 2021, using the modified retrospective method. Under this transition method, the cumulative effect of the accounting change removed the impact of recognizing the equity component of the Company’s convertible notes (at issuance and the subsequent accounting impact of additional interest expense from debt discount amortization). The cumulative effect of the accounting change as of January 1, 2021 increased the carrying amount of the convertible notes by $96.8 million, reduced accumulated deficit by $60.2 million and reduced additional paid-in capital by $157.0 million. Interest expense of the 2024 Notes will be lower as a result of adoption of this guidance. The if-converted method for such instruments will be used to compute diluted net earnings per share if and when profitability is achieved. As a result of the adoption of this guidance, interest expense and net loss was reduced by $22.4 million, or $0.28 per share, for the year ended December 31, 2021. In December 2019, the FASB issued ASU 2019-12, “Income Taxes (Topic 740): Simplifying the Accounting for Income Taxes”, which is intended to simplify the accounting for income taxes. This ASU removes certain exceptions to the general principles in Topic 740 and clarifies and amends existing guidance to improve consistent application. The new guidance was effective beginning January 1, 2021. The adoption of this guidance did not have a material effect on the Company’s consolidated financial statements.

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3. LICENSE AND COLLABORATION AGREEMENTSF. Hoffman-La Roche Ltd.On December 21, 2019, the Company entered into a license, collaboration and option agreement with Roche and a stock purchase agreement (the “Roche Agreement”) with Roche, providing Roche with exclusive commercial rights to SRP-9001, the Company’s investigational gene therapy for Duchenne, outside the U.S. The Company retains all rights to SRP-9001 in the U.S. and will perform all development activities within the joint global development plan necessary to obtain and maintain regulatory approvals for SRP-9001 in the U.S. and the EU, unless otherwise agreed to by the parties. Further: (i) research and development expenses incurred under the joint global development plan will be equally shared between the Company and Roche, (ii) Roche is solely responsible for all costs incurred in connection with any development activities (other than those within the joint global development plan) that are necessary to obtain or maintain regulatory approvals outside the U.S, and (iii) the Company will continue to be responsible for the manufacturing of clinical and commercial supplies of SRP-9001. The Company has also granted Roche options to acquire ex-U.S. rights to certain future Duchenne-specific programs (the “Options”) in exchange for separate option exercise payments, milestone and royalty considerations, and cost sharing provisions. The agreement became effective on February 4, 2020. The Roche Agreement is governed by a joint steering committee (“JSC”) formed by representatives from Roche and the Company. The JSC, among other activities, manages the overall strategic alignment between the parties, approves any material update to the joint global development plan and budget and oversees the operations of the subcommittees. The Company received an aggregate of approximately $1.2 billion in cash consideration from Roche, consisting of an up-front payment and an equity investment in the Company. The Company may receive up to $1.7 billion in development, regulatory and sales milestones related to SRP-9001. Upon commercialization, the Company is also eligible to receive tiered royalty payments based on net sales. Of the $1.2 billion cash received from Roche, (i) $312.1 million, net of issuance costs, was allocated to the approximately 2.5 million shares of the Company’s common stock issued to Roche based on the closing price when the shares were issued, (ii) $485.0 million was allocated to the Options, and (iii) $348.7 million was allocated to a single, combined performance obligation (“Combined Performance Obligation”) comprised of: (i) the license of IP relating to SRP-9001 transferred to Roche, (ii) the related research and development services provided under the joint global development plan, (iii) the services provided to manufacture clinical supplies of SRP-9001, and (iv) the Company’s participation in the JSC, because the Company determined that the license of IP and related activities were not capable of being distinct from one another. The value assigned to the Options is reflected as deferred revenue and will not be recognized until an option is either: (i) exercised by Roche, or (ii) expires. If exercised, the value will be aggregated with the option exercise price and recognized over the applicable performance period. If expired, the value will be recognized immediately. The Company recognizes revenue related to the Combined Performance Obligation on a straight-line basis over the expected performance period of the joint global development plan, which is expected to extend through the fourth quarter of 2023. Revenue relating to future development, regulatory and sales milestones will be recognized when the milestone is probable of achievement (which is typically when the milestone has occurred). Any royalties payable by Roche in the future will be recognized in the period earned.For the years ended December 31, 2021 and 2020, the Company recognized $89.5 million and $84.2 million of collaboration and other revenues, respectively, the majority of which relates to the Combined Performance Obligation. As of December 31, 2021, the Company has total deferred revenue of $663.5 million associated with the Roche Agreement, of which $89.2 million is classified as current. Through 2021, no Options were exercised or expired. As such, deferred revenue related to the separate material rights for the Options remained unchanged at $485.0 million as of December 31, 2021 and 2020.The costs associated with co-development activities performed under the Roche Agreement are included in operating expenses, with any reimbursement of costs by Roche reflected as a reduction of such expenses when the related expense is incurred. For the years ended December 31, 2021 and 2020, costs reimbursable by Roche and reflected as a reduction to operating expenses were $90.5 million and $66.5 million, respectively. As of December 31, 2021, there was $18.6 million of collaboration receivable included in other current assets. GenethonThe Company entered into a sponsored research agreement in May 2017 and subsequently entered into a license and collaboration agreement with Genethon in November 2019 (the “Genethon Collaboration Agreement”) for Genethon’s micro-dystrophin gene therapy program for the treatment of Duchenne. The Genethon Collaboration Agreement grants the Company with exclusive rights in the majority of the world (primarily excluding the EU) to Genethon’s micro-dystrophin gene therapy products (“Genethon Products”) and other micro-dystrophin gene therapy products (“Other Licensed Products”). The Company may be liable for up to $157.5 million and $78.8 million in development, regulatory and sales milestones for the Genethon Products and Other Licensed Products, respectively. Furthermore, upon commercialization, the Company will be required to make tiered royalty payments based on net sales of the Genethon Products and the Other Licensed Products. Under the Genethon Collaboration Agreement, a joint steering committee was established to plan, monitor and coordinate development activities for Genethon Products and Other Licensed Products. The Company and Genethon are responsible for 75% and 25%, respectively, of development costs related to both the Genethon Products and the Other Licensed Products. Upon signing the Genethon Collaboration Agreement, the Company made an up-front payment of $28.0 million, which was recorded as research and development expense in the Company’s consolidated statements of operations and comprehensive loss for the year ended December 31, 2019. Additionally, for the years ended December 31, 2021, 2020 and 2019, the Company recorded $11.7 million, $10.1 million and $9.0 million, respectively, of research and development expense related to reimbursable development costs incurred by Genethon for Genethon Products. For the year ended December 31, 2021, the Company recorded $4.0 million of research and development expense related to milestone achievements. No additional development or regulatory milestones were deemed probable of being achieved and, accordingly, no additional expense has been recognized.StrideBio, Inc.In November 2019, the Company entered into a collaboration and license agreement and a stock purchase agreement (collectively, the “StrideBio Agreements”) with StrideBio, Inc. (“StrideBio”). The StrideBio Agreements grant the Company exclusive worldwide licenses to develop, collaborate and commercialize StrideBio’s adeno-associated viral capsids for gene therapy with respect to multiple development targets, to which the Company will have the exclusive right to perform development activities (“Sarepta Development Targets”) and targets that the two parties will jointly develop through completion of Phase 1/2 clinical trials (“Joint Development Targets”). For Sarepta Development Targets and Joint Development Targets, respectively, the Company may be liable for up to $450.0 million and $835.0 million in development, regulatory and sales milestone payments per target. Additionally, upon commercialization, the Company may be required to make tiered royalty payments based on net sales of each target.Upon signing the StrideBio Agreements, the Company made an up-front payment of $46.9 million, consisting of a cash payment of $17.5 million and 301,980 shares of the Company’s common stock delivered to StrideBio with a fair value of $29.4 million. The up-front payment was recorded as research and development expense in the Company’s consolidated statements of operations and comprehensive loss for the year ended December 31, 2019. As of December 31, 2021, no development or regulatory milestones were deemed probable of being achieved and, accordingly, no additional expense has been recognized. In March 2021, the Company participated in StrideBio’s Series B round of financing and purchased approximately 0.2 million shares of preferred stock. As of December 31, 2021, the equity investment in StrideBio’s Series B preferred stock was approximately $1.8 million. Please read Note 5, Fair Value Measurements for further information.Myonexus TherapeuticsIn April 2019, the Company completed its acquisition of Myonexus Therapeutics, Inc. (“Myonexus”), a clinical-stage gene therapy biotechnology company that was developing gene therapies for LGMD for $178.3 million. The Company may also be required to make up to $200.0 million in additional payments to selling shareholders of Myonexus based on the achievement of certain sales-and regulatory- related milestones. The acquisition was accounted for as an asset acquisition as substantially all of the fair value of the gross assets acquired is concentrated in a group of similar identifiable assets (the five LGMD gene therapy programs). The Company determined that one regulatory-related milestone (not solely based on drug approval by the FDA) met the definition of a derivative and recorded a contingent consideration liability. As of December 31, 2021 and 2020, the contingent consideration liability was $42.0 million and $49.5 million, respectively. The changes in fair value are recorded as other expense in the Company’s consolidated statements of operations and comprehensive loss. Please read Note 5, Fair Value Measurements for further information on the change in fair value of the contingent consideration liability. Lysogene S.A.In October 2018, the Company entered into a license and collaboration agreement to develop and commercialize LYS-SAF302, a gene therapy to treat Mucopolysaccharidosis type IIIA (“MPS IIIA”) as well as an equity investment agreement with Lysogene S.A. (“Lysogene”). Under the license and collaboration agreement, in addition to the payment of up-front fees, the Company may be liable for a total of $102.8 million in development, regulatory and sales milestones. Furthermore, the Company may be required to make tiered royalty payments based on net sales of the LYS-SAF302 product subsequent to its commercialization. Beginning January 1, 2020, the Company began to reimburse Lysogene for expenses incurred in connection with development activities of the MPS IIIA product candidate. As of December 31, 2021, the Company owns 1,140,728 shares of common stock issued by Lysogene and recorded $2.5 million of equity investment in Lysogene as an other non-current asset in the Company’s consolidated balance sheets.The Company sent a termination notice to Lysogene on January 11, 2022 to notify them of the Company's intent to terminate the license and collaboration agreement. The termination will become effective July 11, 2022. The Company does not have to pay any early termination penalties to Lysogene but is liable for certain research and development reimbursements incurred in the six months following termination, which are not expected to be material. As of December 31, 2021, there was no accounting impact as a result of the termination of the license and collaboration agreement because the notice of termination did not occur until subsequent to year-end.Lacerta TherapeuticsIn August 2018, the Company entered into a license, development and option agreement (the “Lacerta License Agreement”) and a Series A Preferred Stock Purchase Agreement (the “Stock Purchase Agreement”) with Lacerta Therapeutics, Inc. (“Lacerta”). Pursuant to the Lacerta License Agreement, the Company licensed exclusive worldwide rights to develop, manufacture and commercialize a pre-clinical Pompe product candidate (the “Pompe License”). Lacerta also granted the Company exclusive options to enter into exclusive license agreements to develop, manufacture and commercialize other gene therapy product candidates for Sanfilipo syndrome and L-Amino Acid Decarboxylase Deficiency for additional consideration of $42.0 million (collectively, the “Options”) when (and if) the Options are exercised. Additionally, the Company may be liable for up to approximately $44.0 million in development, regulatory and sales milestones associated with the Pompe License and may be required to make tiered royalty payments based on net sales of the Pompe product subsequent to its commercialization. Under the Stock Purchase Agreement, the Company purchased approximately 4.5 million shares of Series A preferred stock issued by Lacerta. Under the agreements, the Company made an up-front payment of $38.0 million to Lacerta, of which $30.0 million was allocated to the Series A preferred stock investment and recorded as an other non-current asset in the accompanying consolidated balance sheets. Changes in the carrying value of the investment are reported as a component of earnings whenever there are triggering events that warrant impairment or observable price changes in orderly transactions for identical or similar investments of Lacerta in the future. For the years ended December 31, 2021, 2020 and 2019, the Company did not record any changes in carrying value of the investment as Lacerta did not issue identical or similar shares during the corresponding periods. As of December 31, 2021, no development or regulatory milestones were deemed probable of being achieved and, accordingly, no additional expense has been recognized.Nationwide Children’s Hospital In December 2016, the Company entered into an exclusive option agreement with Nationwide Children’s Hospital (“Nationwide”) from which the Company obtained an exclusive right to acquire a worldwide license of the micro-dystrophin gene therapy technology for Duchenne and Becker muscular dystrophy. In October 2018, the Company exercised the option and entered into a license agreement with Nationwide, which granted the Company exclusive worldwide rights to develop, manufacture and commercialize a micro-dystrophin gene therapy product candidate. In July 2021, the Company entered into an agreement with Nationwide to settle a dispute relating to a sublicense payment owed by the Company resulting from the up-front payment received from Roche under the Roche Agreement. The total sublicense payment payable to Nationwide under the agreement is $38.0 million, which was paid in July 2021. Approximately $9.3 million of this amount was previously expensed during the year ended December 31, 2020 with the remaining $28.7 million expensed during the year ended December 31, 2021. The expense relating to this payment is recognized to research and development expense. As a result of this payment, the Company has no further financial obligations to Nationwide resulting from the up-front payment received under the Roche Agreement. As of December 31, 2021, no development or regulatory milestones were deemed probable of being achieved and, accordingly, no additional in-licensed rights or expenses have been recognized. BioMarin Pharmaceutical, Inc.In July 2017, the Company and UWA entered into a settlement agreement with BioMarin. On the same day, the Company entered into a license agreement, which was subsequently amended in April 2019, with BioMarin and Academisch Ziekenhuis Leiden (“AZL”) (collectively with the Company, UWA and BioMarin, the “Settlement Parties”). Under these agreements and amendment, BioMarin agreed to provide the Company with an exclusive license to certain intellectual property with an option to convert the exclusive license into a co-exclusive license and the Settlement Parties agreed to stop most existing efforts to continue with ongoing litigation and opposition and other administrative proceedings concerning BioMarin’s intellectual property. BioMarin is also eligible to receive tiered royalty payments, ranging from 4% to 8%, based on the net sales for the three products and product candidates. In November 2021, the Company entered into a second settlement agreement and second amendment to the license agreement (the “Second Amendment”), which waived certain future milestone payments and altered royalty payment terms of the agreement. Under the Second Amendment, the Company may be liable for up to approximately $50.0 million in regulatory milestones for eteplirsen, casimersen and golodirsen. In addition, on and after July 1, 2022, the tiered royalty payments will range from 4% to 5%. The royalty terms under the license agreement will expire in March 2024 in the U.S., December 2024 in the EU and no later than December 2024 in other countries.As a result of execution of the license agreement with BioMarin, the Company recorded an in-licensed right intangible asset of $6.6 million in its consolidated balance sheets as of December 31, 2017, representing the fair value of the U.S. license to BioMarin’s intellectual property. The intangible asset is being amortized on a straight-line basis over the remaining life of the patent and has a carrying value of $3.2 million as of December 31, 2021. The FDA approval of AMONDYS 45 and VYONDYS 53 in February 2021 and December 2019, respectively, resulted in settlement charges to BioMarin of $10.0 million during each period and each were expensed as incurred. For the years ended December 31, 2021, 2020 and 2019, the Company recognized royalty expense of $31.4 million, $23.2 million and $19.4 million, respectively. As of December 31, 2021, no other regulatory milestones were deemed probable of being achieved and, accordingly, no additional in-licensed rights or expenses have been recognized. University of Western AustraliaIn April 2013, the Company and UWA entered into an amendment to an existing exclusive license agreement relating to the treatment of Duchenne by inducing the skipping of certain exons. The agreement was further amended in June 2016. Under the amended agreement, the Company may be obligated to make payments to UWA totaling up to $26.0 million upon the achievement of certain development, regulatory and sales milestones. Additionally, the Company is required to pay a low-single-digit percentage royalty on net sales of products covered by issued patents licensed under the agreements with UWA. Corresponding to the FDA approval of EXONDYS 51 in 2016, VYONDYS 53 in December 2019, and AMONDYS 45 in February 2021, the Company recorded milestone payments of $1.0 million, $0.5 million and $0.5 million as in-licensed right intangible assets in its consolidated balance sheets, respectively. Each in-licensed right is being amortized on a straight-line basis over the remaining life of the relevant patents and have a combined carrying value of $1.2 million as of December 31, 2021. For the years ended December 31, 2021, 2020 and 2019, the Company recorded $7.7 million, $<span style="font-size:10.0pt;font-family:Times New Roman;background-color:rgba(0,0,0,0);color:rgba(0,0,0,1);white-space:pre-wrap;font-weight:normal;font-size:10.0pt;font-family:Times New Roman;background-color:rgba(0,0,0,0);color:rgba(0,0,0,1);white-space:pre-wrap;font-weight:normal;font-size:10.0pt;font-family:Times New Roman;">5.7 million and $3.5 million in royalty expense, respectively, which is included in cost of sales, related to agreements with UWA. As of December 31, 2021, no other development, regulatory or sales milestones were deemed probable of being achieved and, accordingly, no additional in-licensed rights or expenses have been recognized.Research and Option AgreementsThe Company has research and option agreements with third parties in order to develop various technologies and biologics that may be used in the administration of the Company’s genetic therapeutics. The agreements generally provide for research services related to pre-clinical development programs, and options to license the technology for clinical development. Prior to the options under these agreements being executed, the Company may be required to make up to $11.0 million in research milestone payments. Under these agreements, there are $187.0 million in potential option payments to be made by the Company upon the determination to exercise the options. Additionally, if the options for each agreement are executed, the Company would incur additional contingent obligations and may be required to make development, regulatory, and sales milestone payments and tiered royalty payments based on the sales of the developed products upon commercialization. For the year ended December 31, 2021, the Company recognized $3.0 million of research milestone expenses, with no similar activity for the years ended December 31, 2020 and 2019. As of December 31, 2021, the Company has not exercised any options nor have any additional research milestone payments become probable of occurring. Milestone ObligationsIncluding the agreements discussed above, the Company has license and collaboration agreements in place for which it could be obligated to pay, in addition to the payment of up-front fees upon execution of the agreements, certain milestone payments as a product candidate proceeds from the submission of an investigational new drug application through approval for commercial sale and beyond. As of December 31, 2021, the Company may be obligated to make up to $4.0 billion of future development, regulatory, commercial, and up-front royalty payments associated with its collaboration and license agreements. These obligations exclude potential future option and milestone payments for options that have yet to be exercised within agreements entered into by the Company as of December 31, 2021, which are discussed above. For the years ended December 31, 2021, 2020 and 2019, the Company recognized approximately $50.3 million, $47.3 million, $113.2 million relating to certain up-front, milestone, settlement and other payments as research and development expense, respectively, under these agreements. The Company is also obligated to pay royalties on net sales of certain of its products related to these collaboration and license agreements. The royalty rates range from the low-single-digit to high teens percentages for both inside and outside the U.S.

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11000000.0 187000000.0 3000000.0 4000000000.0 50300000 47300000 113200000 4. GAIN FROM SALE OF PRIORITY REVIEW VOUCHERIn February 2021, the Company entered into an agreement to sell the rare pediatric disease PRV (the “AMONDYS 45 PRV”) it received from the FDA in connection with the approval of AMONDYS 45. Following the termination of the applicable waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended, in April 2021, the Company completed its sale of the AMONDYS 45 PRV and received proceeds of $102.0 million, with no commission costs, which was recorded as a gain from sale of the PRV as it did not have a carrying value at the time of the sale.In February 2020, the Company entered into an agreement to sell the rare pediatric disease PRV (the “VYONDYS 53 PRV”) it received from the FDA in connection with the approval of VYONDYS 53. Following the early termination of the applicable waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended, in March 2020, the Company completed its sale of the VYONDYS 53 PRV and received proceeds of $108.1 million, net of commission, which was recorded as a gain from sale of the PRV as it did not have a carrying value at the time of the sale. 102000000.0 108100000

5. FAIR VALUE MEASUREMENTSThere were no transfers between Levels 1, 2 and 3 during the year ended December 31, 2021. The tables below present information about the Company’s financial assets and liabilities that are measured and carried at fair value and indicate the level within the fair value hierarchy of the valuation techniques it utilizes to determine such fair value: <div style="font-size:13.5pt;font-family:Times New Roman;"> <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:90.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:32.65%;"/> <td style="width:1.938%;"/> <td style="width:1.412%;"/> <td style="width:17.355%;"/> <td style="width:0.629%;"/> <td style="width:1.371%;"/> <td style="width:1.412%;"/> <td style="width:12.419%;"/> <td style="width:0.629%;"/> <td style="width:1.371%;"/> <td style="width:1.412%;"/> <td style="width:11.419%;"/> <td style="width:0.629%;"/> <td style="width:1.371%;"/> <td style="width:1.412%;"/> <td style="width:11.945%;"/> <td style="width:0.629%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="14" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Fair Value Measurement as of December 31, 2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Total</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Level 1</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Level 2</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Level 3</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="14" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">(in thousands)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;">Assets</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Money market funds</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">1,562,358</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">1,562,358</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Strategic equity investments</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">34,892</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">2,480</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">32,412</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Certificates of deposit</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">250</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">250</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Total assets</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">1,597,500</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">1,565,088</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">32,412</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> <tr> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Liabilities</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Contingent consideration</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">43,600</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">43,600</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Total liabilities</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">43,600</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">43,600</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> <tr> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="14" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Fair Value Measurement as of December 31, 2020</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Total</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Level 1</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Level 2</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Level 3</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="14" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">(in thousands)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;">Assets</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Money market funds</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">629,440</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">629,440</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(204,236,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Government and government agency bonds</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">1,037,981</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">1,037,981</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Strategic equity investments</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">38,799</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">3,699</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">35,100</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;">Certificates of deposit</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">250</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">250</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Total assets</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">1,706,470</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">1,671,370</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">35,100</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> <tr> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Liabilities</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;">Contingent consideration</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">50,800</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">50,800</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">Total liabilities</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">50,800</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">50,800</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table></div> The Company’s assets with fair value categorized as Level 1 within the fair value hierarchy include money market funds, certificates of deposit and the Company’s strategic investment in Lysogene, a publicly traded company in France, as more fully described in Note 3, License and Collaboration Agreements. The Company did not hold any government and government agency bonds as of December 31, 2021. Certain of the government and government agency bonds are publicly traded fixed income securities and were presented as cash equivalents on the consolidated balance sheets as of December 31, 2020.The Company’s assets with fair value categorized as Level 3 within the fair value hierarchy consists of a strategic investment in Series A preferred stock of Lacerta as more fully described in Note 3, License and Collaboration Agreements and strategic investments in another two private companies. At the end of each reporting period, the fair value of the Company's strategic investments will be adjusted if the issuers were to issue similar or identical equity securities or when there is a triggering event for impairment. During the year ended December 31, 2021, the Company recorded an impairment loss of $4.5 million related to its investment in one of the private companies.<div style="font-size:10.0pt;font-family:Times New Roman;">The following table represents a roll-forward of the fair value of Level 3 financial assets for each of the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:84.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:37.941%;"/> <td style="width:3.513%;"/> <td style="width:1.591%;"/> <td style="width:29.798%;"/> <td style="width:1.061%;"/> <td style="width:1.37%;"/> <td style="width:1.591%;"/> <td style="width:22.417%;"/> <td style="width:0.718%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">As of December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">(in thousands)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Fair value, beginning of year</td> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">35,100</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">30,000</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Additions</td> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;">1,800</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;">5,100</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Changes in estimated fair value</td> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(4,488</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">Fair value, end of year</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">32,412</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">35,100</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table> </div>The Company’s contingent consideration liability with fair value categorized as Level 3 within the fair value hierarchy relates to the regulatory-related contingent payments to Myonexus selling shareholders as well as to two academic institutions under separate license agreements that meet the definition of a derivative. For more information related to Myonexus, please read Note 3, License and Collaboration Agreements. The contingent consideration liability was estimated using an income approach based on the probability-weighted expected cash flows that incorporated industry-based probability adjusted assumptions relating to the achievement of the milestone and thus the likelihood of making the payments. This fair value measurement was based upon significant inputs not observable in the market and therefore represented a Level 3 measurement. Significant changes which increase or decrease the probabilities of achieving the milestone or shorten or lengthen the time required to achieve the milestone would result in a corresponding increase or decrease in the fair value of the liability. At the end of each reporting period, the fair value is adjusted to reflect the most current assumptions through earnings. <div style="font-size:10.0pt;font-family:Times New Roman;">The following table represents a roll-forward of the fair value of Level 3 financial liabilities for each of the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:83.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:37.243%;"/> <td style="width:3.555%;"/> <td style="width:1.621%;"/> <td style="width:30.11%;"/> <td style="width:1.073%;"/> <td style="width:2.56%;"/> <td style="width:1.621%;"/> <td style="width:21.5%;"/> <td style="width:0.716%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">As of December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">(in thousands)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Fair value, beginning of year</td> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">50,800</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">5,200</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Additions</td> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;">600</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Changes in estimated fair value, net</td> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(7,200</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">45,000</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">Fair value, end of year</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">43,600</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">50,800</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table></div>A net decrease of $7.2 million and net increase of $45.0 million was recorded during the years ended December 31, 2021 and December 31, 2020, respectively, to account for the change in fair value of existing contingent consideration liabilities. These changes, which are recorded through earnings, were a result of updates made to certain inputs and assumptions impacting the probability-weighted expected cash flows, principally the probability of success of the underlying programs, the estimate of the year that the payments are expected to be made, the expected approval date of the underlying programs and the estimate of the amount of payments to be ultimately made. An increase of $0.6 million was recorded during the year ended December 31, 2020 to account for new contingent consideration liabilities associated with new license agreements with certain academic institutions that meet the definition of a derivative. As of December 31, 2021, the contingent consideration was recorded as a non-current liability on the Company's consolidated balance sheets.The carrying amounts reported in the consolidated balance sheets for cash and cash equivalents, accounts receivable and accounts payable approximate fair value because of the immediate or short-term maturity of these financial instruments. For fair value information related to the Company’s debt facilities, please read Note 13, Indebtedness.

The tables below present information about the Company’s financial assets and liabilities that are measured and carried at fair value and indicate the level within the fair value hierarchy of the valuation techniques it utilizes to determine such fair value: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:90.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:32.65%;"/> <td style="width:1.938%;"/> <td style="width:1.412%;"/> <td style="width:17.355%;"/> <td style="width:0.629%;"/> <td style="width:1.371%;"/> <td style="width:1.412%;"/> <td style="width:12.419%;"/> <td style="width:0.629%;"/> <td style="width:1.371%;"/> <td style="width:1.412%;"/> <td style="width:11.419%;"/> <td style="width:0.629%;"/> <td style="width:1.371%;"/> <td style="width:1.412%;"/> <td style="width:11.945%;"/> <td style="width:0.629%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="14" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Fair Value Measurement as of December 31, 2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Total</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Level 1</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Level 2</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Level 3</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="14" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">(in thousands)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;">Assets</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Money market funds</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">1,562,358</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">1,562,358</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Strategic equity investments</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">34,892</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">2,480</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">32,412</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Certificates of deposit</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">250</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">250</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Total assets</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">1,597,500</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">1,565,088</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">32,412</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> <tr> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Liabilities</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Contingent consideration</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">43,600</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">43,600</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Total liabilities</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">43,600</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">43,600</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> <tr> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="14" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Fair Value Measurement as of December 31, 2020</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Total</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Level 1</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Level 2</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Level 3</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="14" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">(in thousands)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;">Assets</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Money market funds</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">629,440</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">629,440</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(204,236,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Government and government agency bonds</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">1,037,981</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">1,037,981</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Strategic equity investments</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">38,799</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">3,699</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">35,100</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;">Certificates of deposit</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">250</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">250</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Total assets</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">1,706,470</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">1,671,370</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">35,100</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> <tr> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Liabilities</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;">Contingent consideration</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">50,800</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">50,800</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">Total liabilities</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">50,800</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">50,800</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table>

1562358000

34892000

2480000

32412000

250000

1597500000

1565088000

32412000

43600000

629440000

1037981000

38799000

3699000

35100000

250000

1706470000

1671370000

35100000

50800000

4500000

The following table represents a roll-forward of the fair value of Level 3 financial assets for each of the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:84.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:37.941%;"/> <td style="width:3.513%;"/> <td style="width:1.591%;"/> <td style="width:29.798%;"/> <td style="width:1.061%;"/> <td style="width:1.37%;"/> <td style="width:1.591%;"/> <td style="width:22.417%;"/> <td style="width:0.718%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">As of December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">(in thousands)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Fair value, beginning of year</td> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">35,100</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">30,000</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Additions</td> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;">1,800</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;">5,100</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Changes in estimated fair value</td> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(4,488</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">Fair value, end of year</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">32,412</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">35,100</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table>

35100000

30000000

1800000 5100000

-4488000

32412000

35100000

The following table represents a roll-forward of the fair value of Level 3 financial liabilities for each of the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:83.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:37.243%;"/> <td style="width:3.555%;"/> <td style="width:1.621%;"/> <td style="width:30.11%;"/> <td style="width:1.073%;"/> <td style="width:2.56%;"/> <td style="width:1.621%;"/> <td style="width:21.5%;"/> <td style="width:0.716%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">As of December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">(in thousands)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Fair value, beginning of year</td> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">50,800</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">5,200</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Additions</td> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;">600</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Changes in estimated fair value, net</td> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(7,200</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">45,000</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">Fair value, end of year</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">43,600</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">50,800</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table>

50800000

5200000

600000

-7200000

45000000

43600000

50800000

-7200000

45000000.0

600000

6. CASH, CASH EQUIVALENTS AND MARKETABLE SECURITIES<div style="font-size:13.5pt;font-family:Times New Roman;">The following table summarizes the Company’s financial assets with maturities of less than 90 days from the date of purchase included in cash equivalents in the consolidated balance sheets for each of the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:67.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:51.115%;"/> <td style="width:1.787%;"/> <td style="width:2.106%;"/> <td style="width:19.759%;"/> <td style="width:0.928%;"/> <td style="width:1.33%;"/> <td style="width:2.286%;"/> <td style="width:19.759%;"/> <td style="width:0.928%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">As of December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">(in thousands)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Money market funds</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">1,562,358</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">629,440</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Government and government agency bonds</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">602,058</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Total</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">1,562,358</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">1,231,498</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table></div> It is the Company’s policy to mitigate credit risk in its financial assets by maintaining a well-diversified portfolio that limits the amount of exposure as to maturity and investment type. The Company did not hold any available-for-sale securities at December 31, 2021. The weighted average maturity of the Company’s available-for-sale securities as of December 31, 2020 was approximately two months. <div style="font-size:13.5pt;font-family:Times New Roman;">The following tables summarize the Company’s cash, cash equivalents and investments for each of the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:100.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:35.857%;"/> <td style="width:1.438%;"/> <td style="width:1.197%;"/> <td style="width:16.101%;"/> <td style="width:0.594%;"/> <td style="width:1.42%;"/> <td style="width:1.197%;"/> <td style="width:11.479%;"/> <td style="width:0.594%;"/> <td style="width:1.42%;"/> <td style="width:1.197%;"/> <td style="width:11.479%;"/> <td style="width:0.594%;"/> <td style="width:1.42%;"/> <td style="width:1.197%;"/> <td style="width:12.222%;"/> <td style="width:0.594%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="14" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">As of December 31, 2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Amortized Cost</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Gross Unrealized Gains</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Gross Unrealized Losses</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Fair Market Value</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="14" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">(in thousands)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:middle;">Cash and money market funds</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">2,115,869</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">2,115,869</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">Total cash and cash equivalents</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">2,115,869</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">2,115,869</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">As reported:</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:middle;">Cash and cash equivalents</td> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">2,115,869</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">2,115,869</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Total cash and cash equivalents</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">2,115,869</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">2,115,869</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> <tr> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);text-indent:20.0pt;word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="14" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">As of December 31, 2020</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Amortized Cost</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Gross Unrealized Gains</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Gross Unrealized Losses</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Fair Market Value</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="14" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">(in thousands)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:middle;">Cash and money market funds</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">900,590</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">900,590</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:middle;">Government and government agency bonds</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">1,037,959</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">22</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">1,037,981</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Total cash, cash equivalents and investments</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">1,938,549</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">22</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">1,938,571</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">As reported:</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:middle;">Cash and cash equivalents</td> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">1,502,639</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">9</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">1,502,648</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:middle;">Short-term investments</td> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">435,910</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">13</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">435,923</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Total cash, cash equivalents and investments</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">1,938,549</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">22</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">1,938,571</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table></div>

The following table summarizes the Company’s financial assets with maturities of less than 90 days from the date of purchase included in cash equivalents in the consolidated balance sheets for each of the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:67.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:51.115%;"/> <td style="width:1.787%;"/> <td style="width:2.106%;"/> <td style="width:19.759%;"/> <td style="width:0.928%;"/> <td style="width:1.33%;"/> <td style="width:2.286%;"/> <td style="width:19.759%;"/> <td style="width:0.928%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">As of December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">(in thousands)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Money market funds</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">1,562,358</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">629,440</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Government and government agency bonds</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">602,058</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Total</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">1,562,358</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">1,231,498</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table>

1562358000

629440000

602058000

1562358000

1231498000

P2M

The following tables summarize the Company’s cash, cash equivalents and investments for each of the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:100.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:35.857%;"/> <td style="width:1.438%;"/> <td style="width:1.197%;"/> <td style="width:16.101%;"/> <td style="width:0.594%;"/> <td style="width:1.42%;"/> <td style="width:1.197%;"/> <td style="width:11.479%;"/> <td style="width:0.594%;"/> <td style="width:1.42%;"/> <td style="width:1.197%;"/> <td style="width:11.479%;"/> <td style="width:0.594%;"/> <td style="width:1.42%;"/> <td style="width:1.197%;"/> <td style="width:12.222%;"/> <td style="width:0.594%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="14" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">As of December 31, 2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Amortized Cost</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Gross Unrealized Gains</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Gross Unrealized Losses</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Fair Market Value</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="14" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">(in thousands)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:middle;">Cash and money market funds</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">2,115,869</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">2,115,869</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">Total cash and cash equivalents</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">2,115,869</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">2,115,869</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">As reported:</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:middle;">Cash and cash equivalents</td> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">2,115,869</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">2,115,869</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Total cash and cash equivalents</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">2,115,869</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">2,115,869</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> <tr> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);text-indent:20.0pt;word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="14" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">As of December 31, 2020</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Amortized Cost</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Gross Unrealized Gains</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Gross Unrealized Losses</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Fair Market Value</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="14" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">(in thousands)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:middle;">Cash and money market funds</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">900,590</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">900,590</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:middle;">Government and government agency bonds</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">1,037,959</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">22</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">1,037,981</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Total cash, cash equivalents and investments</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">1,938,549</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">22</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">1,938,571</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">As reported:</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:middle;">Cash and cash equivalents</td> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">1,502,639</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">9</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">1,502,648</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:middle;">Short-term investments</td> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">435,910</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">13</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">435,923</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Total cash, cash equivalents and investments</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">1,938,549</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">22</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">1,938,571</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table>

2115869000

2115869000 2115869000 2115869000

2115869000

2115869000 2115869000 900590000

900590000

1037959000

22000

1037981000

1938549000 22000 1938571000 1502639000 9000

1502648000

435910000 13000

435923000

1938549000 22000 1938571000 7. PRODUCT REVENUES, NET, ACCOUNTS RECEIVABLE AND RESERVES FOR PRODUCT REVENUES<div style="font-size:10.0pt;font-family:Times New Roman;">The following table summarizes the Company's product revenues, net disaggregated by product for the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:71.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:34.545%;"/> <td style="width:1.216%;"/> <td style="width:1.935%;"/> <td style="width:19.548%;"/> <td style="width:0.876%;"/> <td style="width:1.216%;"/> <td style="width:1.935%;"/> <td style="width:16.017%;"/> <td style="width:0.771%;"/> <td style="width:1.974%;"/> <td style="width:1.935%;"/> <td style="width:17.259%;"/> <td style="width:0.771%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="10" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">For the Year Ended December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2019</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="10" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;">(in thousands)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">EXONDYS 51</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">454,361</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">422,007</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">380,718</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">VYONDYS 53</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">89,511</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">33,858</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">115</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">AMONDYS 45</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">68,529</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">Products, net</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">612,401</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">455,865</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">380,833</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table></div><div style="font-size:13.5pt;font-family:Times New Roman;">The following table summarizes the components of the Company’s accounts receivable for the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:73.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:59.405%;"/> <td style="width:1.424%;"/> <td style="width:1.895%;"/> <td style="width:17.423%;"/> <td style="width:0.789%;"/> <td style="width:1.793%;"/> <td style="width:1.895%;"/> <td style="width:14.587%;"/> <td style="width:0.789%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">As of December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;">(in thousands)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Product sales receivable, net of discounts and allowances</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">152,990</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">100,870</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Government contract receivables</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">470</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Total accounts receivable, net</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">152,990</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">101,340</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table></div> The relevant government audit was completed and, as a result, the outstanding balance for government contract receivables was received as of December 31, 2021.<div style="font-size:10.0pt;font-family:Times New Roman;">The following table summarizes an analysis of the change in reserves for discounts and allowances for the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:92.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:30.949%;"/> <td style="width:1.12%;"/> <td style="width:1.342%;"/> <td style="width:10.955%;"/> <td style="width:0.908%;"/> <td style="width:1.241%;"/> <td style="width:1.342%;"/> <td style="width:8.776%;"/> <td style="width:0.908%;"/> <td style="width:1.392%;"/> <td style="width:1.342%;"/> <td style="width:10.481%;"/> <td style="width:0.908%;"/> <td style="width:1.241%;"/> <td style="width:1.342%;"/> <td style="width:12.125%;"/> <td style="width:0.908%;"/> <td style="width:1.241%;"/> <td style="width:1.342%;"/> <td style="width:9.23%;"/> <td style="width:0.908%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Chargebacks</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Rebates</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Prompt Pay</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Other Accruals</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Total</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="18" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;">(in thousands)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;">Balance, as of December 31, 2019</td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;text-align:center;">588</td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;text-align:center;">44,738</td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;text-align:center;">1,506</td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;text-align:center;">4,671</td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;text-align:center;">51,503</td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">Provision</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">9,700</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">52,180</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">6,384</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">10,175</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">78,439</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Payments/credits</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(8,007</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(55,147</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(5,941</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(9,877</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(78,972</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;">Balance, as of December 31, 2020</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">2,281</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">41,771</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">1,949</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">4,969</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">50,970</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Provision</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">13,308</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">78,637</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">9,400</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">16,107</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">117,452</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;">Payments/credits</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(14,790</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(59,902</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(8,551</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(14,713</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(97,956</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Balance, as of December 31, 2021</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">799</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">60,506</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">2,798</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">6,363</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">70,466</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table></div> <div style="font-size:10.0pt;font-family:Times New Roman;">The following table summarizes the total reserves above included in the Company’s consolidated balance sheets for the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:74.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:46.733%;"/> <td style="width:2.358%;"/> <td style="width:1.881%;"/> <td style="width:23.316%;"/> <td style="width:0.803%;"/> <td style="width:2.634%;"/> <td style="width:1.881%;"/> <td style="width:19.591%;"/> <td style="width:0.803%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">As of December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;">(in thousands)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Reduction to accounts receivable</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">8,321</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">8,352</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Component of accrued expenses</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">62,145</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">42,618</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Total reserves</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">70,466</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">50,970</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table></div> The following table summarizes the Company's product revenues, net disaggregated by product for the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:71.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:34.545%;"/> <td style="width:1.216%;"/> <td style="width:1.935%;"/> <td style="width:19.548%;"/> <td style="width:0.876%;"/> <td style="width:1.216%;"/> <td style="width:1.935%;"/> <td style="width:16.017%;"/> <td style="width:0.771%;"/> <td style="width:1.974%;"/> <td style="width:1.935%;"/> <td style="width:17.259%;"/> <td style="width:0.771%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="10" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">For the Year Ended December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2019</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="10" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;">(in thousands)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">EXONDYS 51</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">454,361</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">422,007</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">380,718</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">VYONDYS 53</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">89,511</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">33,858</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">115</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">AMONDYS 45</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">68,529</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">Products, net</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">612,401</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">455,865</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">380,833</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table>

454361000

422007000

380718000

89511000

33858000

115000

68529000

612401000

455865000

380833000

152990000

100870000

470000

152990000

101340000

The following table summarizes an analysis of the change in reserves for discounts and allowances for the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:92.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:30.949%;"/> <td style="width:1.12%;"/> <td style="width:1.342%;"/> <td style="width:10.955%;"/> <td style="width:0.908%;"/> <td style="width:1.241%;"/> <td style="width:1.342%;"/> <td style="width:8.776%;"/> <td style="width:0.908%;"/> <td style="width:1.392%;"/> <td style="width:1.342%;"/> <td style="width:10.481%;"/> <td style="width:0.908%;"/> <td style="width:1.241%;"/> <td style="width:1.342%;"/> <td style="width:12.125%;"/> <td style="width:0.908%;"/> <td style="width:1.241%;"/> <td style="width:1.342%;"/> <td style="width:9.23%;"/> <td style="width:0.908%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Chargebacks</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Rebates</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Prompt Pay</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Other Accruals</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Total</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="18" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;">(in thousands)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;">Balance, as of December 31, 2019</td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;text-align:center;">588</td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;text-align:center;">44,738</td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;text-align:center;">1,506</td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;text-align:center;">4,671</td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;text-align:center;">51,503</td> <td style="background-color:rgba(207,240,253,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">Provision</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">9,700</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">52,180</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">6,384</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">10,175</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">78,439</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Payments/credits</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(8,007</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(55,147</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(5,941</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(9,877</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(78,972</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;">Balance, as of December 31, 2020</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">2,281</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">41,771</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">1,949</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">4,969</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);">$</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">50,970</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Provision</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">13,308</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">78,637</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">9,400</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">16,107</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">117,452</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;">Payments/credits</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(14,790</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(59,902</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(8,551</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(14,713</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(97,956</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Balance, as of December 31, 2021</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">799</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">60,506</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">2,798</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">6,363</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">70,466</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table>

588000

44738000

1506000

4671000

51503000

9700000 52180000 6384000 10175000 78439000 -8007000 -55147000 -5941000 -9877000 -78972000

2281000

41771000

1949000

4969000

50970000

13308000 78637000 9400000 16107000 117452000 -14790000 -59902000 -8551000 -14713000 -97956000

799000

60506000

2798000

6363000

70466000

50970000

8. INVENTORY<div style="font-size:13.5pt;font-family:Times New Roman;">The following table summarizes the components of the Company’s inventory for each of the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:66.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:48.741%;"/> <td style="width:1.914%;"/> <td style="width:2.167%;"/> <td style="width:20.656%;"/> <td style="width:0.872%;"/> <td style="width:1.914%;"/> <td style="width:2.167%;"/> <td style="width:20.698%;"/> <td style="width:0.872%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">As of December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="6" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;">(in thousands)</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Raw materials</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">58,822</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">71,717</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Work in progress</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;">230,194</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;">139,704</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Finished goods</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">26,717</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">20,540</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;">Total inventory</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">315,733</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">231,961</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table></div>No material inventory reserves existed as of December 31, 2021 or 2020. Non-current inventory, which consists of raw materials and work in progress, is included in other non-current assets in the Company's consolidated balance sheets. Non-current inventory is anticipated to be consumed beyond our normal operating cycle. As of December 31, 2020, we had no non-current inventory.<div style="font-size:11.0pt;font-family:Times New Roman;">The following table summarizes the balance sheet classification of the Company's inventory for each of the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:64.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:48.462%;"/> <td style="width:1.393%;"/> <td style="width:2.249%;"/> <td style="width:21.198%;"/> <td style="width:0.929%;"/> <td style="width:1.393%;"/> <td style="width:2.249%;"/> <td style="width:21.198%;"/> <td style="width:0.929%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">As of December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="6" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;">(in thousands)</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Balance sheet classification</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Inventory</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;">186,212</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;">231,961</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Other non-current assets</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">129,521</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;">Total inventory</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">315,733</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">231,961</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table></div>

58822000

71717000

230194000

139704000

26717000

20540000

315733000 231961000 The following table summarizes the balance sheet classification of the Company's inventory for each of the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:64.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:48.462%;"/> <td style="width:1.393%;"/> <td style="width:2.249%;"/> <td style="width:21.198%;"/> <td style="width:0.929%;"/> <td style="width:1.393%;"/> <td style="width:2.249%;"/> <td style="width:21.198%;"/> <td style="width:0.929%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">As of December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="6" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;">(in thousands)</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Balance sheet classification</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Inventory</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;">186,212</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;">231,961</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Other non-current assets</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">129,521</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;">Total inventory</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">315,733</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">231,961</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table>

186212000

231961000

129521000

315733000 231961000

The following table summarizes the Company’s other current assets for each of the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:70.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:52.255%;"/> <td style="width:1.936%;"/> <td style="width:1.989%;"/> <td style="width:19.138%;"/> <td style="width:0.796%;"/> <td style="width:1.95%;"/> <td style="width:1.989%;"/> <td style="width:19.151%;"/> <td style="width:0.796%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">As of December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;">(in thousands)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Manufacturing-related deposits and prepaids</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">93,656</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">134,430</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Collaboration receivable</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">18,647</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">34,184</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Prepaid clinical and pre-clinical expenses</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">12,667</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">16,224</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Prepaid maintenance services</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">8,452</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">6,411</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Prepaid insurance</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">5,282</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">4,158</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Prepaid research expenses</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">3,082</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">5,854</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Prepaid income tax</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">1,100</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">4,939</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Leasehold improvement receivable</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">3,059</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Other</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">6,142</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">4,065</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">Total other current assets</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">149,028</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">213,324</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table>

93656000 134430000 18647000 34184000 12667000 16224000 8452000 6411000

5282000

4158000

3082000 5854000

1100000

4939000

0 3059000

6142000

4065000

149028000

213324000

129521000

112765000 148525000 34892000 38799000

9904000

9315000

2007000

3395000

3860000

3669000

292949000

203703000

Property and equipment are recorded at historical cost, net of accumulated depreciation. The following table summarizes components of property and equipment, net, for each of the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:82.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:43.787%;"/> <td style="width:2.467%;"/> <td style="width:1.618%;"/> <td style="width:23.031%;"/> <td style="width:1.086%;"/> <td style="width:2.467%;"/> <td style="width:1.618%;"/> <td style="width:22.838%;"/> <td style="width:1.086%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">As of December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">(in thousands)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Leasehold improvements</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">103,370</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">55,019</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Lab and manufacturing equipment</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">64,613</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">49,571</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Building and improvements</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">47,605</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">39,397</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Software and computer equipment</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">42,506</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">33,948</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Furniture and fixtures</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">9,242</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">7,010</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Land</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">5,183</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">5,183</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Land improvements</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">4,921</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">3,610</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Office equipment</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">1,189</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">1,178</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:middle;">Construction in progress</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">25,159</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">71,541</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">Property and equipment, gross</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">303,788</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">266,457</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:middle;">Less: accumulated depreciation</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(112,632</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(76,027</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">Property and equipment, net</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">191,156</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">190,430</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table>

103370000

55019000

64613000

49571000

47605000

39397000

42506000

33948000

9242000

7010000

5183000

4921000

3610000

1189000

1178000

25159000

71541000

303788000

266457000

112632000

76027000

191156000

190430000

36600000

25200000

22800000

11. INTANGIBLE ASSETS, NET<div style="font-size:10.0pt;font-family:Times New Roman;">The following table summarizes the components of the Company’s intangible assets for each of the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:83.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:44.343%;"/> <td style="width:2.482%;"/> <td style="width:1.621%;"/> <td style="width:22.652%;"/> <td style="width:1.073%;"/> <td style="width:2.482%;"/> <td style="width:1.621%;"/> <td style="width:22.652%;"/> <td style="width:1.073%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">As of December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="6" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;">(in thousands)</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Patents</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">12,382</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">11,210</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">In-licensed rights</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;">8,573</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;">8,073</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Software licenses</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">299</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">1,554</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;">Intangible assets, gross</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;">21,254</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;">20,837</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Less: accumulated amortization</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(7,015</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(7,209</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;">Intangible assets, net</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">14,239</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">13,628</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table></div> The in-licensed rights relate to agreements with BioMarin and UWA. As a result of the FDA approval of EXONDYS 51, VYONDYS 53 and AMONDYS 45, the Company recorded in-licensed rights of $1.0 million, $0.5 million and $0.5 million, respectively. Following the execution of the settlement and license agreements with BioMarin in July 2017, the Company recorded a $6.6 million intangible asset related to EXONDYS 51 in the U.S. The in-licensed rights are being amortized on a straight-line basis over the remaining life of the related patent because the life of the related patent reflects the expected time period that the Company will benefit from the in-licensed right. For more information about the in-licensed rights, please read Note 3, License and Collaboration Agreements. For the years ended December 31, 2021, 2020 and 2019, the Company recorded $0.7 million, $0.7 million and $0.8 million, respectively, of amortization related to the in-licensed rights. Patent amortization expense was $0.6 million, $0.6 million and $0.4 million for the years ended December 31, 2021, 2020 and 2019, respectively. The Company also expensed the remaining net book value of previously capitalized patents that were later abandoned of $0.5 million, $<span style="font-size:10.0pt;font-family:Times New Roman;background-color:rgba(0,0,0,0);color:rgba(0,0,0,1);white-space:pre-wrap;font-weight:normal;font-size:10.0pt;font-family:Times New Roman;background-color:rgba(0,0,0,0);color:rgba(0,0,0,1);white-space:pre-wrap;font-weight:normal;font-size:10.0pt;font-family:Times New Roman;">0.1 million and $0.2 million for the years ended December 31, 2021, 2020 and 2019, respectively, which were included in research and development expenses on the consolidated statements of operations and comprehensive loss.Amortization related to internal use software was less than $0.1 million, $0.5 million and $0.4 million for the years ended December 31, 2021, 2020 and 2019, respectively.<div style="font-size:13.5pt;font-family:Times New Roman;">The following table summarizes the estimated future amortization for intangible assets: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:60.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:67.172%;"/> <td style="width:2.647%;"/> <td style="width:2.476%;"/> <td style="width:26.73%;"/> <td style="width:0.975%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">As of December 31, 2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;">(in thousands)</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">2022</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">1,395</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">2023</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">1,394</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">2024</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">1,391</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">2025</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;text-align:center;">1,330</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">2026</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">1,200</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Thereafter</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">7,529</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Total</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">14,239</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table></div>

12382000

11210000

8573000

8073000

299000

1554000

21254000

20837000

7015000

7209000

14239000

13628000

1000000.0 500000 500000

6600000

700000

800000

600000

400000

500000 100000 200000

100000

500000

400000

The following table summarizes the estimated future amortization for intangible assets: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:60.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:67.172%;"/> <td style="width:2.647%;"/> <td style="width:2.476%;"/> <td style="width:26.73%;"/> <td style="width:0.975%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">As of December 31, 2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;">(in thousands)</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">2022</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">1,395</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">2023</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">1,394</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">2024</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">1,391</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">2025</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;text-align:center;">1,330</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">2026</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">1,200</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Thereafter</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">7,529</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Total</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">14,239</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table>

1395000

1394000

1391000

1330000

1200000

7529000

14239000

The following table summarizes the Company’s accrued expenses for each of the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:70.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:51.81%;"/> <td style="width:1.936%;"/> <td style="width:1.976%;"/> <td style="width:19.387%;"/> <td style="width:0.796%;"/> <td style="width:1.936%;"/> <td style="width:1.976%;"/> <td style="width:19.387%;"/> <td style="width:0.796%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">As of December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;">(in thousands)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Accrued contract manufacturing costs</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">104,311</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">36,543</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Product revenue related reserves</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">62,145</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">42,618</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Accrued employee compensation costs</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">48,299</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">50,803</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Accrued clinical and pre-clinical costs</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">25,955</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">22,169</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Accrued royalties</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">11,965</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">7,793</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Accrued professional fees</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">9,381</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">10,221</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Accrued collaboration cost-sharing</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">2,887</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">3,516</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Accrued interest expense</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">1,045</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">1,045</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Accrued milestone and license expense</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">100</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">9,380</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Other</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">5,609</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">9,465</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Total accrued expenses</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">271,697</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">193,553</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table>

104311000 36543000 62145000 42618000

48299000

50803000

25955000 22169000

11965000

7793000

9381000

10221000

2887000 3516000

1045000

100000 9380000

5609000

9465000

271697000

193553000

13. INDEBTEDNESS 2024 Convertible NotesOn November 14, 2017, the Company issued $570.0 million senior notes due on November 15, 2024. The 2024 Notes were issued at face value and bear interest at the rate of 1.50% per annum, payable semi-annually in cash on each May 15 and November 15, commencing on May 15, 2018. The 2024 Notes contain customary covenants and events of default, occurrence of which permits the certain holders to accelerate all outstanding obligations, including principal and interest. The Company incurred $10.6 million of offering costs, which represents the total debt discount on the 2024 Notes at issuance. The debt discount is amortized under the effective interest method and recorded as additional interest expense over the life of the 2024 Notes.Upon conversion, the Company may pay cash, shares of its common stock or a combination of cash and stock, as determined by the Company in its discretion. The 2024 Notes may be convertible into 7,763,552 shares of the Company’s common stock under certain circumstances prior to maturity at a conversion rate of 13.621 shares per $1,000 principal amount of the 2024 Notes, which represents a conversion price of $73.42 per share, subject to adjustment under certain conditions.To minimize the impact of potential dilution upon conversion of the 2024 Notes, the Company separately entered into capped call transactions with certain counterparties. The capped calls have a strike price of $73.42 and a cap price of $104.88 and are exercisable when and if the 2024 Notes are converted. If, upon conversion of the 2024 Notes, the price of the Company’s common stock is between the strike price and the cap price of the capped calls, the counterparties will deliver shares of the Company’s common stock and/or cash with an aggregate value equal to the difference between the price of the Company’s common stock at the conversion date and the strike price, multiplied by the number of shares of the Company’s common stock related to the capped calls being exercised. The Company paid $50.9 million for these capped calls transactions, which was recorded as additional paid-in capital.Upon adoption of ASU 2020-06, the 2024 Notes are accounted for as a single liability measured at its amortized cost. The cumulative effect of the accounting change as of January 1, 2021 increased the carrying amount of the convertible notes by $96.8 million, reduced the accumulated deficit by $60.2 million and reduced additional paid-in capital by $157.0 million. Upon adoption of ASU 2020-06, the effective interest rate on the liability component of the 2024 Notes for the year ended December 31, 2021 was 1.9%. The effective interest rate on the liability component of the 2024 Notes for each of the years ended December 31, 2020 and 2019 was 6.9%. Interest expense of the 2024 Notes was reduced by $22.4 million for the year ended December 31, 2021 as a result of adoption of this guidance. For the years ended December 31, 2021, 2020 and 2019, the interest expense related to the 2024 Notes was $10.7 million, $31.4 million and $29.9 million, respectively. December 2019 Term LoanOn December 13, 2019, the Company entered into a loan agreement (the “Credit Agreement”) which provides a term loan (“December 2019 Term Loan”) of $500.0 million with Biopharma Credit PLC and Biopharma Credit Investments V (Master) LP (collectively, the “Lenders”). The December 2019 Term Loan has two tranches: A and B, each of which had an initial loan amount of $250.0 million. On September 24, 2020, the Company entered into a first amendment to Credit Agreement (the “Amendment”),which increased the aggregate principal amount of tranche B of the December 2019 Term Loan from $250.0 million to $300.0 million and revised certain fees. Tranche A and B of the December 2019 Term Loan were drawn down on December 20, 2019 and November 2, 2020 and will mature on December 20, 2023 and December 31, 2024, respectively, when the principal amount of the loan will become due. Borrowings under the Credit Agreement bear interest at a rate per annum equal to 8.5%, which shall be payable quarterly in arrears. The Company may voluntarily prepay, in whole or in part, the outstanding balance under the December 2019 Term Loan at any time after the tranche A closed but may be obligated to make additional financial considerations to the Lenders.Upon draw-down of tranche A and B, the Company received net proceeds of $244.9 million and $291.1 million, net of debt discounts of $9.4 million and $14.9 million relating to fees payable to the Lenders, respectively. Of the fees payable to the Lenders related to tranche A and B, $5.0 million and $6.0 million are expected to be paid on December 20, 2023 and December 31, 2024, respectively. The debt discounts are being treated as a reduction to the carrying value of tranche A and B of the December 2019 Term Loan and amortized as interest expense over the term of the loan based on an effective interest method. Debt issuance costs associated with the draw-down of tranche A and B were $0.7 million and less than $0.1 million, respectively.As of December 31, 2021, the Company recorded approximately $1,096.9 million as long-term debt on the consolidated balance sheets. For the years ended December 31, 2021, 2020 and 2019, the Company recorded $63.5 million, $59.9 million and $30.7 million of interest expense, respectively.<div style="font-size:13.5pt;font-family:Times New Roman;">The following table summarizes the Company’s debt facilities for the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:80.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:56.248%;"/> <td style="width:1.671%;"/> <td style="width:18.552%;"/> <td style="width:1.114%;"/> <td style="width:1.183%;"/> <td style="width:1.671%;"/> <td style="width:18.448%;"/> <td style="width:1.114%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">As of December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">(in thousands)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Principal amount of the 2024 Notes</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">569,993</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">569,993</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Unamortized discount - equity component</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">(98,721</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">)</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Unamortized discount - debt issuance costs</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(6,320</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(6,510</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">Net carrying value of 2024 Notes</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">563,673</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">464,762</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Principal amount of the 2019 Term Loan</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">550,000</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">550,000</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Unamortized discounts</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(16,797</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(22,269</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Net carrying value of 2019 Term Loan</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">533,203</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">527,731</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">Total carrying value of debt facilities</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">1,096,876</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">992,493</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> <tr> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Fair value of 2024 Notes</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">846,138</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">1,394,249</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Fair value of 2019 Term Loan</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">576,085</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">550,000</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">Total fair value of debt facilities</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">1,422,223</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">1,944,249</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table></div> The fair value of the 2024 Notes is based on open market trades and is classified as Level 1 in the fair value hierarchy. The fair value of the December 2019 Term Loan is classified as Level 2 in the fair value hierarchy and is determined using a discounted cash flow analysis with market interest rates adjusted for credit risk as a significant input.<div style="font-size:13.5pt;font-family:Times New Roman;">The following table summarizes the total gross payments due under the Company’s debt arrangements: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:60.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:68.514%;"/> <td style="width:2.353%;"/> <td style="width:2.446%;"/> <td style="width:25.728%;"/> <td style="width:0.96%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">As of December 31, 2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;">(in thousands)</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">2022</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:middle;">2023</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">250,000</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">2024</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">869,993</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:middle;">2025</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">2026</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:middle;">Thereafter</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Total payments</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">1,119,993</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table>The aggregate annual maturities of long-term debt and interest during the years ending December 31, 2022, 2023 and 2024 are $55.9 million, $305.3 million and $903.4 million, respectively. </div>

570000000.0

2024-11-15

0.0150

The 2024 Notes contain customary covenants and events of default, occurrence of which permits the certain holders to accelerate all outstanding obligations, including principal and interest.

10600000

7763552

0.013621

73.42

104.88

50900000 96800000 60200000 157000000.0

0.019

0.069

22400000

10700000

31400000

29900000

500000000.0

250000000.0

300000000.0

2023-12-20

2024-12-31

0.085

244900000

291100000

9400000

14900000

5000000.0

6000000.0

700000

100000

1096900000

63500000

59900000

30700000

The following table summarizes the Company’s debt facilities for the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:80.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:56.248%;"/> <td style="width:1.671%;"/> <td style="width:18.552%;"/> <td style="width:1.114%;"/> <td style="width:1.183%;"/> <td style="width:1.671%;"/> <td style="width:18.448%;"/> <td style="width:1.114%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">As of December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">(in thousands)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Principal amount of the 2024 Notes</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">569,993</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">569,993</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Unamortized discount - equity component</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">(98,721</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">)</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Unamortized discount - debt issuance costs</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(6,320</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(6,510</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">Net carrying value of 2024 Notes</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">563,673</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">464,762</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Principal amount of the 2019 Term Loan</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">550,000</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">550,000</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Unamortized discounts</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(16,797</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(22,269</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Net carrying value of 2019 Term Loan</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">533,203</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">527,731</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">Total carrying value of debt facilities</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">1,096,876</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">992,493</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> <tr> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Fair value of 2024 Notes</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">846,138</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">1,394,249</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Fair value of 2019 Term Loan</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">576,085</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">550,000</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">Total fair value of debt facilities</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">1,422,223</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">1,944,249</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table>

569993000

98721000

6320000

6510000

563673000

464762000

550000000

16797000

22269000

533203000

527731000

1096876000

992493000

846138000

1394249000

576085000

550000000

1422223000

1944249000

The following table summarizes the total gross payments due under the Company’s debt arrangements: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:60.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:68.514%;"/> <td style="width:2.353%;"/> <td style="width:2.446%;"/> <td style="width:25.728%;"/> <td style="width:0.96%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">As of December 31, 2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;">(in thousands)</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">2022</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:middle;">2023</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">250,000</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">2024</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">869,993</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:middle;">2025</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">2026</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:middle;">Thereafter</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Total payments</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">1,119,993</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table>The aggregate annual maturities of long-term debt and interest during the years ending December 31, 2022, 2023 and 2024 are $55.9 million, $305.3 million and $903.4 million, respectively.

250000000

869993000

1119993000

55900000

305300000

903400000

7100000

81.00

548500000

26500000

2500000

312100000

4300000

300000

29400000

2600000

140.41

365400000

300000

15. STOCK-BASED COMPENSATIONIn June 2013, the Company’s stockholders approved the 2013 Employee Stock Purchase Plan (the “2013 ESPP”) which authorized 0.3 million shares of common stock available to be issued. In June 2016 and 2019, the Company’s stockholders approved an additional 0.3 million and 0.5 million shares, respectively, of common stock available for issuance under the 2013 ESPP. As of December 31, 2021, 0.4 million shares of common stock remain available for future grant under the 2013 ESPP.In September 2014, the Company initiated the 2014 Employment Commencement Incentive Plan (the “2014 Plan”). The 2014 Plan, which authorized 0.6 million shares of common stock to be issued and allows for the grant of stock options, SARs, RSAs, RSUs, performance shares and performance units. As of December 31, 2021, 7.0 million shares have been added to the Company's 2014 Plan. As of December 31, 2021, 1.5 million shares of common stock remain available for future grant under the 2014 Plan. In June 2018, the Company’s stockholders approved the 2018 Equity Incentive Plan (the “2018 Plan”). The 2018 Plan, which authorized 2.9 million shares of common stock to be issued, allows for the grant of stock options, SARs, RSAs, RSUs, performance shares and performance units. In June 2020, an additional 3.8 million shares of common stock were approved by the Company’s stockholders and added to the 2018 Plan. Together with the roll-over shares from the Company’s 2011 Equity Incentive Plan, 4.2 million shares of common stock remain available for future grant under the 2018 Plan as of December 31, 2021.Stock OptionsIn general, stock options have a ten-year term and vest over a four-year period, with one-fourth of the underlying shares vesting on the first anniversary of the grant and 1/48th of the underlying shares vesting monthly thereafter, such that the underlying shares will be fully vested on the fourth anniversary of the grant, subject to the terms of the applicable plan under which they were granted.<div style="font-size:13.5pt;font-family:Times New Roman;">The fair values of stock options granted during the periods presented are measured on the date of grant using the Black-Scholes-Merton option-pricing model, with the following assumptions: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:67.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:49.203%;"/> <td style="width:1.677%;"/> <td style="width:15.256%;"/> <td style="width:1.677%;"/> <td style="width:15.256%;"/> <td style="width:1.677%;"/> <td style="width:15.256%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="5" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">For the Year Ended December 31,</td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2019</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Risk-free interest rate (1)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">0.4 - 1.3%</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">0.1 - 1.3%</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">1.4 - 2.5%</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">Expected dividend yield (2)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">— </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">— </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">— </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Expected term (3)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">4.99 years</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">5.00 years</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">5.04 years</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">Expected volatility (4)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">60.1 - 70.8%</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">57.3 - 68.2%</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">52.5 - 68.9%</td> </tr> </table> <div style="display:flex;margin-top:0.0pt;line-height:1.1020833333333333;justify-content:flex-start;align-items:baseline;margin-bottom:0.0pt;min-width:4.537%;text-align:left;"><span style="background-color:rgba(0,0,0,0);color:rgba(0,0,0,1);white-space:pre-wrap;font-weight:normal;font-size:10.0pt;font-family:Times New Roman;display:inline-flex;font-size:10.0pt;font-family:Times New Roman;justify-content:flex-start;min-width:4.537%;">(1)<div style="display:inline;">The risk-free interest rate is estimated using an average of Treasury bill interest rates over a historical period commensurate with the expected term of the option that correlates to the prevailing interest rates at the time of grant.</div></div><div style="display:flex;margin-top:0.0pt;line-height:1.1020833333333333;justify-content:flex-start;align-items:baseline;margin-bottom:0.0pt;min-width:4.537%;text-align:left;"><span style="background-color:rgba(0,0,0,0);color:rgba(0,0,0,1);white-space:pre-wrap;font-weight:normal;font-size:10.0pt;font-family:Times New Roman;display:inline-flex;font-size:10.0pt;font-family:Times New Roman;justify-content:flex-start;min-width:4.537%;">(2)<div style="display:inline;">The expected dividend yield is zero as the Company has not paid any dividends to date and does not expect to pay dividends in the future.</div></div><div style="display:flex;margin-top:0.0pt;line-height:1.1020833333333333;justify-content:flex-start;align-items:baseline;margin-bottom:0.0pt;min-width:4.537%;text-align:left;"><span style="background-color:rgba(0,0,0,0);color:rgba(0,0,0,1);white-space:pre-wrap;font-weight:normal;font-size:10.0pt;font-family:Times New Roman;display:inline-flex;font-size:10.0pt;font-family:Times New Roman;justify-content:flex-start;min-width:4.537%;">(3)<div style="display:inline;">The expected term is estimated using historical exercise behavior. </div></div><div style="display:flex;margin-top:0.0pt;line-height:1.1020833333333333;justify-content:flex-start;align-items:baseline;margin-bottom:0.0pt;min-width:4.537%;text-align:left;"><span style="background-color:rgba(0,0,0,0);color:rgba(0,0,0,1);white-space:pre-wrap;font-weight:normal;font-size:10.0pt;font-family:Times New Roman;display:inline-flex;font-size:10.0pt;font-family:Times New Roman;justify-content:flex-start;min-width:4.537%;">(4)<div style="display:inline;">The expected volatility is the implied volatility in exchange-traded options of the Company’s common stock. </div></div></div>The amounts estimated according to the Black-Scholes-Merton option-pricing model may not be indicative of the actual values realized upon the exercise of these options by the holders.<div style="font-size:13.5pt;font-family:Times New Roman;">The following tables summarize the Company’s stock option activity for each of the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:82.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:49.349%;"/> <td style="width:2.218%;"/> <td style="width:0.724%;"/> <td style="width:21.641%;"/> <td style="width:1.087%;"/> <td style="width:2.218%;"/> <td style="width:1.63%;"/> <td style="width:20.407%;"/> <td style="width:0.724%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">For the Year Ended December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;">Weighted</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;">Average</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;">Exercise</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Shares</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Price</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Grants outstanding at beginning of the period</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">7,844,947</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">70.61</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:15.0pt;word-break:break-word;vertical-align:middle;">Granted</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">1,685,860</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">86.41</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:15.0pt;word-break:break-word;vertical-align:middle;">Exercised</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">(283,622</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">45.71</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:15.0pt;word-break:break-word;vertical-align:middle;">Cancelled and forfeited</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(1,050,264</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">112.18</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Grants outstanding at end of the period</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">8,196,921</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">69.39</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Grants exercisable at end of the period</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">2,532,438</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">84.71</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">Grants vested and expected to vest at end of the period</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">7,867,722</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">68.17</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> </table> The weighted-average grant date fair value per share of stock options granted during the years ended December 31, 2021, 2020 and 2019 was $48.16, $61.38 and $70.93, respectively. <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:88.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:56.421%;"/> <td style="width:1.887%;"/> <td style="width:1.466%;"/> <td style="width:16.617%;"/> <td style="width:0.664%;"/> <td style="width:4.197%;"/> <td style="width:0.696%;"/> <td style="width:17.387%;"/> <td style="width:0.664%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">Weighted</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">Aggregate</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">Average</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">Intrinsic</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">Remaining</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">Value</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">Contractual</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">(in thousands)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Life (Years)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Options outstanding at December 31, 2021</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">248,479</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">6.4</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">Options exercisable at December 31, 2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">59,069</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">5.6</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Options vested and expected to vest at December 31, 2021</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">247,434</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">6.3</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> </table> </div> <div style="font-size:10.0pt;font-family:Times New Roman;">The following table summarizes the Company’s stock options vested and exercised for each of the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:88.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:46.357%;"/> <td style="width:1.55%;"/> <td style="width:1.455%;"/> <td style="width:13.466%;"/> <td style="width:0.654%;"/> <td style="width:3.417%;"/> <td style="width:1.455%;"/> <td style="width:13.667%;"/> <td style="width:0.654%;"/> <td style="width:1.55%;"/> <td style="width:1.455%;"/> <td style="width:13.667%;"/> <td style="width:0.654%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="10" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">For the Year Ended December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2019</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="10" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;">(in thousands)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Aggregate grant date fair value of stock options vested</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">79,068</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">80,355</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">50,878</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">Aggregate intrinsic value of stock options exercised</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">10,622</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">144,750</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">109,707</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> </table></div> As of December 31, 2021, there were 3,300,000 options with service and market conditions included in the grants outstanding for the Company’s CEO, which have a five-year cliff vesting schedule and a grant date fair value of $13.48 determined by a lattice model with Monte Carlo simulations. These options have an exercise price of $34.65 and were granted in June 2017. Restricted Stock AwardsThe Company has granted RSAs to members of its board of directors and certain employees. The following table summarizes the Company’s RSA activity for each of the periods indicated:<div style="font-size:13.5pt;font-family:Times New Roman;"> <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:79.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:47.715%;"/> <td style="width:2.315%;"/> <td style="width:0.752%;"/> <td style="width:21.925%;"/> <td style="width:1.151%;"/> <td style="width:2.315%;"/> <td style="width:1.715%;"/> <td style="width:21.361%;"/> <td style="width:0.752%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">For the Year Ended December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;">Weighted</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;">Average</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;">Grant Date</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Shares</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Fair Value</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Grants outstanding at beginning of the period</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">48,875</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">50.11</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:15.0pt;word-break:break-word;vertical-align:middle;">Granted</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:15.0pt;word-break:break-word;vertical-align:middle;">Vested</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">(48,875</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">50.11</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:15.0pt;word-break:break-word;vertical-align:middle;">Forfeited</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Grants outstanding at end of the period</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> </table> </div>Restricted Stock UnitsThe Company grants RSUs to members of its board of directors and employees. The following table summarizes the Company’s RSU activity for the periods indicated: <div style="font-size:13.5pt;font-family:Times New Roman;"> <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:80.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:48.068%;"/> <td style="width:2.262%;"/> <td style="width:0.743%;"/> <td style="width:22.126%;"/> <td style="width:1.125%;"/> <td style="width:2.262%;"/> <td style="width:1.682%;"/> <td style="width:20.989%;"/> <td style="width:0.743%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">For the Year Ended December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;">Weighted</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;">Average</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;">Grant Date</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Shares</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Fair Value</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Grants outstanding at beginning of the period</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">947,079</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">121.46</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:15.0pt;word-break:break-word;vertical-align:middle;">Granted</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">987,464</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">85.32</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:15.0pt;word-break:break-word;vertical-align:middle;">Vested</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">(276,980</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">119.54</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:15.0pt;word-break:break-word;vertical-align:middle;">Forfeited</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(337,357</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">106.37</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Grants outstanding at end of the period</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">1,320,206</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">98.69</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> </table></div>2013 Employee Stock Purchase PlanUnder the Company’s 2013 ESPP, participating employees purchase common stock through payroll deductions. The purchase price is equal to 85% of the lower of the closing price of the Company’s common stock on the first business day and the last business day of the relevant purchase period. The 24-month offering period will end on August 31, 2023. The following table summarizes the Company’s ESPP activity for each of the periods indicated:<div style="font-size:13.5pt;font-family:Times New Roman;"> <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:78.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:46.877%;"/> <td style="width:1.285%;"/> <td style="width:1.737%;"/> <td style="width:14.337%;"/> <td style="width:0.75%;"/> <td style="width:1.202%;"/> <td style="width:1.737%;"/> <td style="width:13.801%;"/> <td style="width:0.952%;"/> <td style="width:1.202%;"/> <td style="width:1.737%;"/> <td style="width:13.432%;"/> <td style="width:0.952%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="10" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">For the Year Ended December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2019</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Number of shares purchased</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">111,171</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">102,031</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">92,086</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">Proceeds received (in millions)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">7.8</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">7.5</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">5.1</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> </table></div> Stock-based Compensation Expense<div style="font-size:13.5pt;font-family:Times New Roman;">The following table summarizes stock-based compensation expense by function included within the consolidated statements of operations and comprehensive loss: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:80.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:47.431%;"/> <td style="width:1.404%;"/> <td style="width:1.659%;"/> <td style="width:13.722%;"/> <td style="width:0.835%;"/> <td style="width:1.404%;"/> <td style="width:1.659%;"/> <td style="width:13.722%;"/> <td style="width:0.835%;"/> <td style="width:1.427%;"/> <td style="width:1.659%;"/> <td style="width:13.398%;"/> <td style="width:0.847%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="10" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">For the Year Ended December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2019</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="10" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">(in thousands)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:middle;">Research and development</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">50,526</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">41,671</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">27,681</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:middle;">Selling, general and administrative</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">63,417</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">66,399</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">50,921</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Total stock-based compensation</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">113,943</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">108,070</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">78,602</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table></div> <div style="font-size:13.5pt;font-family:Times New Roman;">The following table summarizes stock-based compensation expense by grant type included within the consolidated statements of operations and comprehensive loss: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:80.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:47.227%;"/> <td style="width:1.415%;"/> <td style="width:1.659%;"/> <td style="width:13.77%;"/> <td style="width:0.835%;"/> <td style="width:1.415%;"/> <td style="width:1.659%;"/> <td style="width:13.77%;"/> <td style="width:0.835%;"/> <td style="width:1.439%;"/> <td style="width:1.659%;"/> <td style="width:13.457%;"/> <td style="width:0.858%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="10" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">For the Year Ended December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2019</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="10" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">(in thousands)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:top;"> Stock options</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">68,995</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">68,832</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">53,427</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:top;"> Restricted stock awards/units</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">40,055</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">33,457</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">20,103</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:top;"> Employee stock purchase plan</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">4,893</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">5,781</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">5,072</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:top;"> Total stock-based compensation</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">113,943</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">108,070</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">78,602</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table></div> As of December 31, 2021, there was $175.7 million of total unrecognized stock-based compensation expense related to the Company’s stock-based compensation plans. The expense is expected to be recognized over a weighted-average period of approximately 3 years. Of this amount, $92.4 million relates to options with service conditions only, $4.3 million relates to awards with service and market conditions, and the remaining $79.0 million related to restricted stock units with service conditions only.

300000

500000

400000

600000

7000000.0

1500000

2900000

3800000

P10Y

P4Y

The fair values of stock options granted during the periods presented are measured on the date of grant using the Black-Scholes-Merton option-pricing model, with the following assumptions: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:67.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:49.203%;"/> <td style="width:1.677%;"/> <td style="width:15.256%;"/> <td style="width:1.677%;"/> <td style="width:15.256%;"/> <td style="width:1.677%;"/> <td style="width:15.256%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="5" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">For the Year Ended December 31,</td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2019</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Risk-free interest rate (1)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">0.4 - 1.3%</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">0.1 - 1.3%</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">1.4 - 2.5%</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">Expected dividend yield (2)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">— </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">— </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">— </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Expected term (3)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">4.99 years</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">5.00 years</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">5.04 years</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">Expected volatility (4)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">60.1 - 70.8%</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">57.3 - 68.2%</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">52.5 - 68.9%</td> </tr> </table> <div style="display:flex;margin-top:0.0pt;line-height:1.1020833333333333;justify-content:flex-start;align-items:baseline;margin-bottom:0.0pt;min-width:4.537%;text-align:left;"><span style="background-color:rgba(0,0,0,0);color:rgba(0,0,0,1);white-space:pre-wrap;font-weight:normal;font-size:10.0pt;font-family:Times New Roman;display:inline-flex;font-size:10.0pt;font-family:Times New Roman;justify-content:flex-start;min-width:4.537%;">(1)<div style="display:inline;">The risk-free interest rate is estimated using an average of Treasury bill interest rates over a historical period commensurate with the expected term of the option that correlates to the prevailing interest rates at the time of grant.</div></div><div style="display:flex;margin-top:0.0pt;line-height:1.1020833333333333;justify-content:flex-start;align-items:baseline;margin-bottom:0.0pt;min-width:4.537%;text-align:left;"><span style="background-color:rgba(0,0,0,0);color:rgba(0,0,0,1);white-space:pre-wrap;font-weight:normal;font-size:10.0pt;font-family:Times New Roman;display:inline-flex;font-size:10.0pt;font-family:Times New Roman;justify-content:flex-start;min-width:4.537%;">(2)<div style="display:inline;">The expected dividend yield is zero as the Company has not paid any dividends to date and does not expect to pay dividends in the future.</div></div><div style="display:flex;margin-top:0.0pt;line-height:1.1020833333333333;justify-content:flex-start;align-items:baseline;margin-bottom:0.0pt;min-width:4.537%;text-align:left;"><span style="background-color:rgba(0,0,0,0);color:rgba(0,0,0,1);white-space:pre-wrap;font-weight:normal;font-size:10.0pt;font-family:Times New Roman;display:inline-flex;font-size:10.0pt;font-family:Times New Roman;justify-content:flex-start;min-width:4.537%;">(3)<div style="display:inline;">The expected term is estimated using historical exercise behavior. </div></div><div style="display:flex;margin-top:0.0pt;line-height:1.1020833333333333;justify-content:flex-start;align-items:baseline;margin-bottom:0.0pt;min-width:4.537%;text-align:left;"><span style="background-color:rgba(0,0,0,0);color:rgba(0,0,0,1);white-space:pre-wrap;font-weight:normal;font-size:10.0pt;font-family:Times New Roman;display:inline-flex;font-size:10.0pt;font-family:Times New Roman;justify-content:flex-start;min-width:4.537%;">(4)<div style="display:inline;">The expected volatility is the implied volatility in exchange-traded options of the Company’s common stock. </div></div>

0.004

0.013

0.001

0.013

0.014

0.025

P4Y11M26D

P5Y

P5Y14D

0.601

0.708

0.573

0.682

0.525

0.689

The following tables summarize the Company’s stock option activity for each of the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:82.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:49.349%;"/> <td style="width:2.218%;"/> <td style="width:0.724%;"/> <td style="width:21.641%;"/> <td style="width:1.087%;"/> <td style="width:2.218%;"/> <td style="width:1.63%;"/> <td style="width:20.407%;"/> <td style="width:0.724%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">For the Year Ended December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;">Weighted</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;">Average</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;">Exercise</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Shares</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Price</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Grants outstanding at beginning of the period</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">7,844,947</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">70.61</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:15.0pt;word-break:break-word;vertical-align:middle;">Granted</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">1,685,860</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">86.41</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:15.0pt;word-break:break-word;vertical-align:middle;">Exercised</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">(283,622</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">45.71</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:15.0pt;word-break:break-word;vertical-align:middle;">Cancelled and forfeited</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(1,050,264</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">112.18</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Grants outstanding at end of the period</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">8,196,921</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">69.39</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Grants exercisable at end of the period</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">2,532,438</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">84.71</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">Grants vested and expected to vest at end of the period</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">7,867,722</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">68.17</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> </table> The weighted-average grant date fair value per share of stock options granted during the years ended December 31, 2021, 2020 and 2019 was $48.16, $61.38 and $70.93, respectively. <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:88.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:56.421%;"/> <td style="width:1.887%;"/> <td style="width:1.466%;"/> <td style="width:16.617%;"/> <td style="width:0.664%;"/> <td style="width:4.197%;"/> <td style="width:0.696%;"/> <td style="width:17.387%;"/> <td style="width:0.664%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">Weighted</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">Aggregate</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">Average</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">Intrinsic</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">Remaining</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">Value</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">Contractual</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">(in thousands)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Life (Years)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Options outstanding at December 31, 2021</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">248,479</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">6.4</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">Options exercisable at December 31, 2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">59,069</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">5.6</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Options vested and expected to vest at December 31, 2021</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">247,434</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">6.3</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> </table>

7844947

70.61

1685860

86.41

283622

45.71

1050264

112.18

8196921

69.39

2532438

84.71

7867722

68.17

61.38

70.93

248479000

P6Y4M24D

59069000

P5Y7M6D

247434000

P6Y3M18D

79068000 80355000 50878000

10622000

144750000

109707000

3300000

13.48

34.65

The following table summarizes the Company’s RSA activity for each of the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:79.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:47.715%;"/> <td style="width:2.315%;"/> <td style="width:0.752%;"/> <td style="width:21.925%;"/> <td style="width:1.151%;"/> <td style="width:2.315%;"/> <td style="width:1.715%;"/> <td style="width:21.361%;"/> <td style="width:0.752%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">For the Year Ended December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;">Weighted</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;">Average</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;">Grant Date</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Shares</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Fair Value</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Grants outstanding at beginning of the period</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">48,875</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">50.11</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:15.0pt;word-break:break-word;vertical-align:middle;">Granted</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:15.0pt;word-break:break-word;vertical-align:middle;">Vested</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">(48,875</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">50.11</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:15.0pt;word-break:break-word;vertical-align:middle;">Forfeited</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Grants outstanding at end of the period</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> </table>

48875

50.11

48875

50.11

The following table summarizes the Company’s RSU activity for the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:80.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:48.068%;"/> <td style="width:2.262%;"/> <td style="width:0.743%;"/> <td style="width:22.126%;"/> <td style="width:1.125%;"/> <td style="width:2.262%;"/> <td style="width:1.682%;"/> <td style="width:20.989%;"/> <td style="width:0.743%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">For the Year Ended December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;">Weighted</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;">Average</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;">Grant Date</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Shares</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">Fair Value</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Grants outstanding at beginning of the period</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">947,079</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">121.46</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:15.0pt;word-break:break-word;vertical-align:middle;">Granted</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">987,464</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">85.32</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:15.0pt;word-break:break-word;vertical-align:middle;">Vested</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">(276,980</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">119.54</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:15.0pt;word-break:break-word;vertical-align:middle;">Forfeited</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(337,357</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">106.37</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Grants outstanding at end of the period</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">1,320,206</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">98.69</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> </table>

947079

121.46

987464

85.32

276980

119.54

337357

106.37

1320206

98.69

0.85

P24M

2023-08-31

The following table summarizes the Company’s ESPP activity for each of the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:78.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:46.877%;"/> <td style="width:1.285%;"/> <td style="width:1.737%;"/> <td style="width:14.337%;"/> <td style="width:0.75%;"/> <td style="width:1.202%;"/> <td style="width:1.737%;"/> <td style="width:13.801%;"/> <td style="width:0.952%;"/> <td style="width:1.202%;"/> <td style="width:1.737%;"/> <td style="width:13.432%;"/> <td style="width:0.952%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="10" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">For the Year Ended December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2019</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Number of shares purchased</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">111,171</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">102,031</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">92,086</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">Proceeds received (in millions)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">7.8</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">7.5</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">5.1</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> </table>

111171

102031

92086

7800000

7500000

5100000

50526000

41671000

27681000

63417000

66399000

50921000

113943000

108070000

78602000

68995000

68832000

53427000

40055000

33457000

20103000

4893000

5781000

5072000

113943000

108070000

78602000

175700000

92400000

4300000

79000000.0

The Company sponsors a 401(k) Plan (“the Plan”) in the U.S. and other retirement plans in the rest of the world, all of which are defined contribution plans. The Plan is available to all employees who are age 21 or older. Participants may make voluntary contributions and the Company makes matching contributions according to the Plan’s matching formula. Matching contributions fully vest after one year of service for all employees. The expense related to the Plan primarily consists of the Company’s matching contributions.

P1Y

5300000

3400000

17. OTHER INCOME (LOSS)<div style="font-size:13.5pt;font-family:Times New Roman;">The following table summarizes other income (loss) for the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:80.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:46.114%;"/> <td style="width:1.45%;"/> <td style="width:1.647%;"/> <td style="width:13.817%;"/> <td style="width:1.09%;"/> <td style="width:1.45%;"/> <td style="width:1.647%;"/> <td style="width:13.817%;"/> <td style="width:1.09%;"/> <td style="width:1.45%;"/> <td style="width:1.647%;"/> <td style="width:13.689%;"/> <td style="width:1.09%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="10" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">For the Year Ended December 31,</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2019</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="10" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;">(in thousands)</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Interest expense</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">(63,525</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">(59,947</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">(30,669</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">)</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Interest income</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">354</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">2,970</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">7,238</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Amortization of investment discount</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">157</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">4,489</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">15,350</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Gain from sale of Priority Review Voucher</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">102,000</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">108,069</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Gain (loss) on contingent consideration, net*</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">7,200</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">(45,000</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Impairment of equity investment</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">(4,488</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(204,236,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Other (expense) income</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(936</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">517</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(236</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">Total other income (loss)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">40,762</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">11,098</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">(8,317</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(255,255,255,0.01);">)</td> </tr> </table></div>

The following table summarizes other income (loss) for the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:80.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:46.114%;"/> <td style="width:1.45%;"/> <td style="width:1.647%;"/> <td style="width:13.817%;"/> <td style="width:1.09%;"/> <td style="width:1.45%;"/> <td style="width:1.647%;"/> <td style="width:13.817%;"/> <td style="width:1.09%;"/> <td style="width:1.45%;"/> <td style="width:1.647%;"/> <td style="width:13.689%;"/> <td style="width:1.09%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="10" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">For the Year Ended December 31,</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2019</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="10" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;">(in thousands)</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Interest expense</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">(63,525</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">(59,947</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">(30,669</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">)</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Interest income</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">354</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">2,970</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">7,238</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Amortization of investment discount</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">157</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">4,489</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">15,350</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Gain from sale of Priority Review Voucher</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">102,000</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">108,069</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Gain (loss) on contingent consideration, net*</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">7,200</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">(45,000</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Impairment of equity investment</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">(4,488</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(204,236,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Other (expense) income</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(936</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">517</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(236</td> <td style="background-color:rgba(204,236,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">Total other income (loss)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">40,762</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">11,098</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">(8,317</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(255,255,255,0.01);">)</td> </tr> </table>

63525000

59947000

30669000

354000

2970000

7238000

157000 4489000 15350000

102000000

108069000

7200000 -45000000

4488000

-936000

517000

-236000

40762000

11098000

-8317000

18. INCOME TAXES<div style="font-size:13.5pt;font-family:Times New Roman;">The following table summarizes the loss before the provision (benefit) for income taxes by jurisdiction for the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:80.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:45.684%;"/> <td style="width:1.381%;"/> <td style="width:1.659%;"/> <td style="width:13.944%;"/> <td style="width:1.102%;"/> <td style="width:1.369%;"/> <td style="width:1.659%;"/> <td style="width:13.968%;"/> <td style="width:1.102%;"/> <td style="width:1.369%;"/> <td style="width:1.659%;"/> <td style="width:14.002%;"/> <td style="width:1.102%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="10" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">For the Year Ended December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2019</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="10" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">(in thousands)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Domestic</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">(47,633</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">(204,956</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">(489,747</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">)</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Foreign</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(371,315</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(348,109</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(224,133</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Total</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">(418,948</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">(553,065</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">(713,880</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);">)</td> </tr> </table> </div> <div style="font-size:13.5pt;font-family:Times New Roman;">The following table summarizes provision (benefit) for income taxes in the accompanying consolidated financial statements for the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:80.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:47.321%;"/> <td style="width:1.45%;"/> <td style="width:1.682%;"/> <td style="width:13.118%;"/> <td style="width:1.125%;"/> <td style="width:1.427%;"/> <td style="width:1.682%;"/> <td style="width:13.396%;"/> <td style="width:1.125%;"/> <td style="width:1.427%;"/> <td style="width:1.682%;"/> <td style="width:13.442%;"/> <td style="width:1.125%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="10" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">For the Year Ended December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2019</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="10" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">(in thousands)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Current provision:</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Federal</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">4</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">State</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">(40</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">624</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">521</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Foreign</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">181</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">680</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">1,050</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Total current provision</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">141</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">1,308</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">1,571</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">Deferred benefit:</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Federal</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">(15</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">)</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">State</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">(5</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">)</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Foreign</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(309</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(245</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(356</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">Total deferred benefit</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(309</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(245</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(376</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Total income tax (benefit) expense</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">(168</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">1,063</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">1,195</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table></div> <div style="font-size:13.5pt;font-family:Times New Roman;">The following table summarizes the reconciliation between the Company’s effective tax rate and the statutory income tax rate for each of the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:80.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:47.437%;"/> <td style="width:1.38%;"/> <td style="width:0.719%;"/> <td style="width:12.329%;"/> <td style="width:1.113%;"/> <td style="width:1.937%;"/> <td style="width:1.38%;"/> <td style="width:0.719%;"/> <td style="width:12.329%;"/> <td style="width:1.113%;"/> <td style="width:1.937%;"/> <td style="width:1.38%;"/> <td style="width:0.719%;"/> <td style="width:12.329%;"/> <td style="width:1.113%;"/> <td style="width:2.064%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="12" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">For the Year Ended December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2019</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Federal income tax rate</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">21.0</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">%</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">21.0</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">%</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">21.0</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">%</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">State taxes</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">0.4</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">0.6</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">4.5</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Research and development and other tax credits</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">10.0</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">10.1</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">5.1</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Valuation allowance</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">(9.8</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">(21.3</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">(16.8</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Permanent differences</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">(0.3</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">(1.6</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">2.3</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Stock-based compensation</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">(3.0</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">3.5</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">(0.6</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Basis difference in subsidiary</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">(8.4</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Foreign rate differential</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">(18.4</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">(12.9</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">(7.4</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Other</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">0.1</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">0.4</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">0.1</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">Effective tax rate</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">(0.0</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">%</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">(0.2</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">%</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">(0.2</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">%</td> </tr> </table></div> Permanent differences affecting the Company’s effective tax rate primarily include excess stock-based compensation tax deductions, net of non-deductible stock-based compensation and limitation on deductibility of officer compensations. In February 2019, the Company exercised its option to acquire Myonexus. Accumulated costs of $253.7 million, associated with the Myonexus acquisition, were expensed for U.S. GAAP purposes. Of the $253.7 million in accumulated costs, $85.0 million relates to up-front and milestone payments as a result of the execution of the Warrant Agreement in May 2018 as well as certain development milestones being achieved or becoming probable of being achieved and $168.7 million relates to the exercise of the exclusive option to acquire Myonexus in February 2019. For U.S. income tax purposes, these costs are considered to be an investment in the subsidiary and are not currently deductible for tax purposes. The permanent difference related to this acquisition is separately stated in the rate reconciliation above.<div style="font-size:13.5pt;font-family:Times New Roman;">The following table summarizes the analysis of the deferred tax assets and liabilities for each of the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:70.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:55.836%;"/> <td style="width:1.525%;"/> <td style="width:1.976%;"/> <td style="width:17.268%;"/> <td style="width:1.313%;"/> <td style="width:1.525%;"/> <td style="width:1.976%;"/> <td style="width:17.268%;"/> <td style="width:1.313%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">As of December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">(in thousands)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Deferred tax assets:</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:middle;">Net operating loss carryforwards</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">330,392</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">333,703</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:middle;">Difference in depreciation and amortization</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">31,563</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">31,259</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:middle;">Research and development tax credits</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">201,512</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">159,917</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:middle;">Stock-based compensation</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">38,132</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">31,212</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:middle;">Lease liabilities</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">10,890</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">13,120</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:middle;">Capitalized inventory</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">24,172</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">35,959</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:middle;">Debt discount</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">5,875</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:middle;">Other</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">38,315</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">28,381</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">Total deferred tax assets</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">680,851</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">633,551</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Deferred tax liabilities:</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:middle;">Right of use asset</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">(7,405</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">(8,772</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">)</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:middle;">Debt discount</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(18,044</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">Total deferred tax liabilities</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">(7,405</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">(26,816</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">)</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Valuation allowance</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(672,319</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(605,848</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">Net deferred tax assets</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">1,127</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">887</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table></div> The Company has evaluated the positive and negative evidence bearing upon the realizability of its U.S. net deferred tax assets, which are comprised principally of federal and state net operating loss carryforwards, research and development tax credit carryforwards, stock-based compensation expense, capitalized inventory, and intangibles. Under the applicable accounting standards, management has considered the Company’s history of losses and concluded that it is more likely than not that the Company will not recognize the benefits of net federal and state deferred tax assets. Accordingly, a full valuation allowance of the U.S. net deferred tax asset is maintained at December 31, 2021 and 2020. The net change in the valuation allowance for deferred tax assets was an increase of $66.5 million and $117.0 million for the years ended December 31, 2021 and 2020, respectively. This increase for the year ended December 31, 2021 was primarily due to the generation of federal and state income tax credits and a decrease in the debt discount deferred tax liability that was recorded through additional paid-in capital as a result of the Company's early adoption of ASU 2020-06. The Company generated foreign deferred tax assets mainly consisting of net operating loss carryforwards, stock-based compensation and unrealized gain/losses. Based upon the income projections in the majority of the foreign jurisdictions, the Company believes it will realize the benefit of its future deductible differences in these jurisdictions. As such, the Company has not recorded a valuation allowance against these foreign jurisdictions. Brazil, the Netherlands, Czech Republic and one of the entities in the United Kingdom have generated deferred tax assets, which consist of net operating loss carryforwards and stock-based compensation expense. The Company has concluded that it is more likely than not that we will not recognize the future benefits of the deferred tax assets, and accordingly, a full valuation allowance has been recorded against these foreign deferred tax assets. As of December 31, 2021, the Company had federal and state net operating loss carryforwards of $1,280.4 million and $841.2 million, respectively, available to reduce future taxable income. The federal and state net operating loss carry forwards of $577.2 million and $797.0 million will expire at various dates between 2022 and 2041. The federal and state net operating loss carryforwards of $703.2 million and $44.2 million, respectively, can be carried forward indefinitely. Utilization of these net operating losses could be limited under Section 382 of the Internal Revenue Code and similar state laws based on historical or future ownership changes and the value of the Company’s stock. Additionally, the Company has $139.2 million and $77.0 million of federal and state research and development credits, respectively, available to offset future taxable income. These federal and state research and development credits begin to expire between 2022 and 2041 and between 2022 and 2036, respectively. The Company also has foreign net operating loss carryforwards of $13.6 million, mainly derived from the net operating loss generated by its subsidiary in Brazil, which may be carried forward indefinitely.The Company, or one of its subsidiaries, files income tax returns in the U.S., and various state and foreign jurisdictions. The federal, state and foreign income tax returns are generally subject to tax examinations for the tax years ended December 31, 2018 through December 31, 2021. To the extent the Company has tax attribute carryforwards, the tax years in which the attribute was generated may still be adjusted upon examination by the Internal Revenue Service, state or foreign tax authorities to the extent utilized in a future period.<div style="font-size:13.5pt;font-family:Times New Roman;">The follow table summarizes the reconciliation of the beginning and ending amount of total unrecognized tax benefits for each of the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:80.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:46.909%;"/> <td style="width:1.438%;"/> <td style="width:1.67%;"/> <td style="width:13.548%;"/> <td style="width:1.114%;"/> <td style="width:1.438%;"/> <td style="width:1.67%;"/> <td style="width:13.548%;"/> <td style="width:0.893%;"/> <td style="width:1.404%;"/> <td style="width:1.67%;"/> <td style="width:13.583%;"/> <td style="width:1.114%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="10" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">For the Year Ended December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2019</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="10" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">(in thousands)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Balance at beginning of the period</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">48,475</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">41,753</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">37,544</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Increase related to current year tax positions</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">5,503</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">6,722</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">4,275</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Increase related to prior year tax positions</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">109</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;">Decrease related to prior year tax positions</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(163</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(175</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Balance at end of the period</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">53,815</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">48,475</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">41,753</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table></div>The balance of total unrecognized tax benefits at December 31, 2021, if recognized, would not affect the effective tax rate on income from continuing operations, due to a full valuation allowance against the Company’s U.S. deferred tax assets. The Company does not expect that the amount of unrecognized tax benefits to change significantly in the next twelve months. The Company’s policy is to recognize interest and/or penalties related to income tax matters in income tax expense. It had no accrual for interest or penalties on its consolidated balance sheets at December 31, 2021 or 2020. No interest and/or penalties were recognized in 2021 or 2020.The Company’s intent is to only make distributions from non-U.S. subsidiaries in the future when they can be made at no net tax cost. Otherwise, the Company considers all of its foreign earnings to be permanently reinvested outside of the U.S. and has no plans to repatriate these foreign earnings to the U.S. The Company has no material unremitted earnings from its non-U.S. subsidiaries.The Tax Cuts and Jobs Act created a new provision that certain income earned by foreign subsidiaries, known as global intangible low-tax income, must be included in the gross income of their U.S. shareholder. The Company has adopted a policy to account for this provision as a period cost.

-47633000

-204956000

-489747000

-371315000

-348109000

-224133000

-418948000

-553065000

-713880000

4000

-40000

624000

-521000

181000

680000

1050000

141000

1308000

1571000

-15000

-5000

-309000

-245000

-356000

-309000

-245000

-376000

-168000

1063000

1195000

0.210

0.004

0.006

0.045

0.100 0.101 0.051

-0.098

-0.213

-0.168

-0.003 -0.016 0.023

-0.030

0.035

-0.006

-0.084

-0.184

-0.129

-0.074

0.001

0.004

0.001

-0.000

-0.002

0.002

253700000 253700000 85000000.0 168700000

The following table summarizes the analysis of the deferred tax assets and liabilities for each of the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:70.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:55.836%;"/> <td style="width:1.525%;"/> <td style="width:1.976%;"/> <td style="width:17.268%;"/> <td style="width:1.313%;"/> <td style="width:1.525%;"/> <td style="width:1.976%;"/> <td style="width:17.268%;"/> <td style="width:1.313%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">As of December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="6" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;">(in thousands)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Deferred tax assets:</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:middle;">Net operating loss carryforwards</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">330,392</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">333,703</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:middle;">Difference in depreciation and amortization</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">31,563</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">31,259</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:middle;">Research and development tax credits</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">201,512</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">159,917</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:middle;">Stock-based compensation</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">38,132</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">31,212</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:middle;">Lease liabilities</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">10,890</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">13,120</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:middle;">Capitalized inventory</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">24,172</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">35,959</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:middle;">Debt discount</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">5,875</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:middle;">Other</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">38,315</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">28,381</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">Total deferred tax assets</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">680,851</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">633,551</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Deferred tax liabilities:</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:middle;">Right of use asset</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">(7,405</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">(8,772</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">)</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:middle;">Debt discount</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(18,044</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">Total deferred tax liabilities</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">(7,405</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;text-align:center;">(26,816</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">)</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">Valuation allowance</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(672,319</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(605,848</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;">Net deferred tax assets</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">1,127</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">887</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:middle;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table>

330392000

333703000

31563000 31259000

201512000

159917000

38132000

31212000

10890000 13120000

24172000

35959000

5875000

38315000

28381000

680851000

633551000

7405000 8772000 18044000

7405000

26816000

672319000

605848000

1127000

887000

66500000

117000000.0

1280400000

841200000

577200000

797000000.0

2022 2041

703200000

44200000

139200000

77000000.0

These federal and state research and development credits begin to expire between 2022 and 2041 and between 2022 and 2036, respectively.

13600000

48475000

41753000

37544000

5503000

6722000

4275000

109000

163000

175000

53815000

48475000

41753000

45500000

56600000

The following table contains a summary of the lease costs recognized and other information pertaining to the Company’s operating leases for the periods indicated: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:80.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:47.795%;"/> <td style="width:2.019%;"/> <td style="width:1.683%;"/> <td style="width:20.005%;"/> <td style="width:2.808%;"/> <td style="width:1.195%;"/> <td style="width:1.683%;"/> <td style="width:20.005%;"/> <td style="width:2.808%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="6" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">For the Year Ended December 31,</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:middle;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="6" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;">(in thousands)</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Lease cost</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Operating lease cost</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;">28,737</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;">18,978</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Variable lease cost</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">18,742</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">17,065</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;">Total lease cost</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;">47,479</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;">36,043</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;">Other information</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Operating lease payments</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">24,449</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">19,344</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Operating lease liabilities arising from obtaining ROU assets</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;">13,225</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;">59,327</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Weighted average remaining lease term</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">3.5 years</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">4.6 years</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Weighted average discount rate</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;">7.6</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;">%</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;">7.6</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;">%</td> </tr> </table>

28737000

18978000

18742000

17065000

47479000

36043000

24449000

19344000

13225000

59327000

P3Y6M

P4Y7M6D

0.076

The following table summarizes maturities of lease liabilities and the reconciliation of lease liabilities as of December 31, 2021: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:80.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:69.49%;"/> <td style="width:2.1%;"/> <td style="width:1.705%;"/> <td style="width:25.568%;"/> <td style="width:1.137%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">For the Year Ended December 31, 2021</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;">(in thousands)</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">2022</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">18,702</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">2023</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;">18,326</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">2024</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">17,582</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">2025</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:center;">9,052</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">2026</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">571</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Thereafter</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">—</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Total minimum lease payments</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">64,233</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Less: imputed interest</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">(7,672</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);">)</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Total operating lease liabilities</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">56,561</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;">Included in the consolidated balance sheet:</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Current portion of lease liabilities within other current liabilities</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">15,049</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Lease liabilities</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">41,512</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Total operating lease liabilities</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">56,561</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table>

18702000

18326000

17582000

9052000

571000

64233000

7672000

56561000

15049000

41512000

56561000

20. NET LOSS PER SHAREBasic net loss per share is computed by dividing net loss by the weighted-average number of shares of common stock outstanding. Diluted net loss per share is computed by dividing net loss by the weighted-average number of shares of common stock and dilutive common stock equivalents outstanding. Given that the Company recorded a net loss for each of the periods presented, there is no difference between basic and diluted net loss per share since the effect of common stock equivalents would be anti-dilutive and are, therefore, excluded from the diluted net loss per share calculation.<div style="font-size:13.5pt;font-family:Times New Roman;"> <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:80.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:52.929%;"/> <td style="width:1.137%;"/> <td style="width:1.659%;"/> <td style="width:11.774%;"/> <td style="width:1.102%;"/> <td style="width:1.125%;"/> <td style="width:1.659%;"/> <td style="width:11.785%;"/> <td style="width:1.102%;"/> <td style="width:1.125%;"/> <td style="width:1.659%;"/> <td style="width:11.843%;"/> <td style="width:1.102%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="10" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">For the Year Ended December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2019</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="10" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;">(in thousands, except per share amounts)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Net loss</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">(418,780</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">(554,128</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">(715,075</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">)</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">Weighted-average common shares outstanding - basic</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">81,262</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">77,956</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">73,615</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Effect of dilutive securities*</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">Weighted-average common shares outstanding - diluted</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">81,262</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">77,956</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">73,615</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Net loss per share — basic and diluted</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">(5.15</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">(7.11</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">(9.71</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">)</td> </tr> </table> * For the years ended December 31, 2021, 2020 and 2019, stock options, RSAs, RSUs and ESPP to purchase approximately 9.7 million, 9.0 million and 9.1 million shares of common stock, respectively, were excluded from the net loss per share calculation as their effect would have been anti-dilutive. The Company accounts for the effect of the 2024 Notes on diluted net earnings per share using the if-converted method as this obligation may be settled in cash or shares at the Company’s option. The effect of potential share settlement is included in the diluted net earnings per share calculation if the effect is more dilutive. During the year ended December 31, 2021, the inclusion of the potential share settlement of the 2024 Notes was anti-dilutive. Accordingly, the potential conversion of 7,763,552 shares has been excluded from the computation of diluted net earnings per share as of December 31, 2021.</div>

Given that the Company recorded a net loss for each of the periods presented, there is no difference between basic and diluted net loss per share since the effect of common stock equivalents would be anti-dilutive and are, therefore, excluded from the diluted net loss per share calculation. <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:80.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:52.929%;"/> <td style="width:1.137%;"/> <td style="width:1.659%;"/> <td style="width:11.774%;"/> <td style="width:1.102%;"/> <td style="width:1.125%;"/> <td style="width:1.659%;"/> <td style="width:11.785%;"/> <td style="width:1.102%;"/> <td style="width:1.125%;"/> <td style="width:1.659%;"/> <td style="width:11.843%;"/> <td style="width:1.102%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="10" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">For the Year Ended December 31,</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2020</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">2019</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="10" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;">(in thousands, except per share amounts)</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Net loss</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">(418,780</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">(554,128</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">(715,075</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">)</td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">Weighted-average common shares outstanding - basic</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">81,262</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">77,956</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">73,615</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Effect of dilutive securities*</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">—</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;">Weighted-average common shares outstanding - diluted</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">81,262</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">77,956</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">73,615</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Net loss per share — basic and diluted</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">(5.15</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">(7.11</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">)</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;text-align:center;">(9.71</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:middle;">)</td> </tr> </table> * For the years ended December 31, 2021, 2020 and 2019, stock options, RSAs, RSUs and ESPP to purchase approximately 9.7 million, 9.0 million and 9.1 million shares of common stock, respectively, were excluded from the net loss per share calculation as their effect would have been anti-dilutive. The Company accounts for the effect of the 2024 Notes on diluted net earnings per share using the if-converted method as this obligation may be settled in cash or shares at the Company’s option. The effect of potential share settlement is included in the diluted net earnings per share calculation if the effect is more dilutive. During the year ended December 31, 2021, the inclusion of the potential share settlement of the 2024 Notes was anti-dilutive. Accordingly, the potential conversion of 7,763,552 shares has been excluded from the computation of diluted net earnings per share as of December 31, 2021.

-418780000

-554128000

-715075000

81262000

77956000

73615000

81262000

77956000

73615000

-5.15

-7.11

-9.71

9700000

9000000.0

9100000

7763552

21. COMMITMENTS AND CONTINGENCIESManufacturing ObligationsThe Company has entered into long-term contractual arrangements from time to time for the provision of goods and services. Thermo Fisher Scientific, Inc.The Company entered into a development, commercial manufacturing, and supply agreement in June 2018 and, subsequently, entered into the first and second amendments in May 2019 and July 2020, respectively, with Thermo, formerly Brammer Bio MA, LLC (collectively, the “Thermo Agreements”). Pursuant to the terms of the Thermo Agreements, the Company had access to substantially all of the facility’s eight clean room suites for the Company’s gene therapy programs, subject to certain minimum and maximum volume limitations. The Company determined that the Thermo Agreements contained a lease because the Company had the right to direct the use of the facility and related equipment therein. The lease on four of the eight dedicated clean room suites at Thermo commenced during 2020 and the remaining four commenced during 2021, which is when the dedicated clean room suites became available for use by the Company.In October 2021, the Company executed a third amendment (the “Amendment”) that modified the terms of the Thermo Agreements. The modification significantly decreased the Company’s right of use of the facility’s capacity and significantly reduced the fixed and in-substance fixed payments due over the remaining term of the agreement. The modification was accounted for as a lease termination, resulting in: (i) the derecognition of right of use assets of $23.4 million, (ii) the derecognition of lease liabilities of $20.1 million, and (iii) the recognition of a loss of $3.3 million, which is included in research and development expense. In addition, as a result of the capacity changes associated with the Amendment, $21.1 million of accelerated amortization of nonrefundable advance payments made to Thermo that were previously recorded as other assets in the accompanying consolidated balance sheets were charged to research and development expense.Under the Amendment, the Thermo Agreements will expire on December 31, 2028, or earlier if certain conditions are met. The Company has the ability to extend the term with an 18-months’ notice and an agreement between the two parties. The Company also has the ability to terminate the Thermo Agreements prior to expiration, subject to the payment of additional financial consideration. Further, the Company has committed to guaranteed purchases under the Amendment on a take-or-pay basis regardless of whether services or goods are ordered. As of December 31, 2021, the Company believes it is probable that the guaranteed purchase requirements will be met in the normal course of business throughout the term of the agreement. Catalent, Inc.The Company entered into a manufacturing collaboration agreement and, subsequently, entered into a manufacturing and supply agreement with Catalent, formerly Paragon Biosciences, Inc. in October 2018 and February 2019, respectively (collectively, the “Catalent Agreements”). Pursuant to the terms of the Catalent Agreements, Catalent agreed to provide the Company with two dedicated clean room suites and an option to reserve two additional clean room suites for its gene therapy programs, subject to certain minimum and maximum volume limitations. In September 2019, the Company exercised the option to gain access to the two additional clean room suites. The Catalent Agreements will expire on December 31, 2024. The Company has the ability to terminate the Catalent Agreements prior to expiration, subject to the payment of additional financial consideration. The Company determined that the Catalent Agreements contained a lease because the Company had the right to direct the use of the facility and related equipment therein. The lease on all four dedicated clean room suites at Catalent commenced during 2020, which is when the dedicated clean room suites became available for use by the Company.In March 2021, the Company modified the terms of the Catalent Agreements. The modification decreased the Company’s right of use of certain dedicated clean room suites and reduced the fixed and in-substance fixed payments due over the remaining term of the agreement. The modification was accounted for as a partial lease termination, resulting in: (i) the derecognition of right of use assets of $22.8 million, (ii) the derecognition of lease liabilities of $20.0 million, and (iii) the recognition of a loss of $2.8 million, which is included in research and development expense. Aldevron, LLCThe Company entered into a clinical and commercial supply agreement in December 2018, as subsequently amended in June 2020, with Aldevron LLC (“Aldevron”) for the supply of plasmid DNA to fulfill its needs for gene therapy clinical trials and commercial supply (collectively, the “Aldevron Agreements”). Pursuant to the terms of the Aldevron Agreements, Aldevron agreed to reserve a certain amount of manufacturing capacity on a quarterly basis. In return, the Company is required to make advance payments to Aldevron related to the manufacturing capacity. The term of the Aldevron Agreements will expire on December 31, 2026. The Company has the option to extend the term of the Aldevron Agreements by one year if the Company delivers a written notice of its intention to extend to Aldevron no later than June 1, 2025. Both parties have the right to early terminate without additional penalty. The Company has determined that the Aldevron Agreements do not contain an embedded lease because it does not convey the right to control the use of Aldevron’s facility or related equipment therein. <div style="font-size:13.5pt;font-family:Times New Roman;">The following table presents non-cancelable contractual obligations arising from long-term contractual arrangements, including obligations related to leases embedded in certain supply agreements: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:60.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:70.789%;"/> <td style="width:3.576%;"/> <td style="width:2.415%;"/> <td style="width:22.291%;"/> <td style="width:0.929%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">As of December 31, 2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;">(in thousands)</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">2022</td> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">647,124</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">2023</td> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">178,345</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">2024</td> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">138,725</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">2025</td> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">100,838</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">2026</td> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">54,720</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Thereafter</td> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">109,440</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Total manufacturing commitments</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">1,229,192</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table></div> Additionally, should the Company obtain regulatory approval for any drug product candidate produced as a part of the Company’s manufacturing obligations above, additional minimum batch requirements with the respective manufacturing parties would be required.Other Funding CommitmentsThe Company has several on-going clinical trials in various clinical trial stages. Its most significant clinical trial expenditures are to contract research organizations (“CROs”). The CRO contracts are generally cancellable at the Company’s option. As of December 31, 2021, the Company has approximately $378.5 million in cancellable future commitments based on existing CRO contracts. For the years ended December 31, 2021, 2020 and 2019, the Company recognized approximately $47.9 million, $40.4 million and $31.6 million, respectively, for expenditures incurred by CROs. Litigation In the normal course of business, the Company may from time to time be named as a party to various legal claims, actions and complaints, including matters involving securities, employment, intellectual property, arising from the use of therapeutics utilizing its technology, or others. We record a loss contingency reserve for a legal proceeding when we consider the potential loss probable and we can reasonably estimate the amount of the loss or determine a probable range of loss. We provide disclosure when we consider a loss reasonably possible or when we determine that a loss in excess of a reserve is reasonably possible. We provide an estimate of such reasonably possible losses or an aggregate range of such reasonably possible losses, unless we believe that such an estimate cannot be made. The Company has not recorded any material accruals for loss contingencies and in management's opinion no material range of loss is estimable for the matters described below as of December 31, 2021.On September 15, 2020, REGENXBIO INC. (“RegenX”) and the Trustees of the University of Pennsylvania filed a lawsuit against the Company and Sarepta Therapeutics Three, LLC (together, “Sarepta”), in the U.S. District Court for the District of Delaware. The plaintiffs assert patent infringement of U.S. Patent No. 10,526,617 (“the ‘617 Patent”) under 35 U.S.C.§§ 271(a)-(c) based on Sarepta’s alleged direct or indirect manufacture and use of the patented cultured host cell technology allegedly used to make adeno-associated virus (“AAV”) gene therapy products, including SRP-9001. Specifically, the Complaint essentially includes the allegation that Sarepta’s use, and the use by its contract manufacturers on its behalf, of a host cell containing a recombinant acid molecule that encodes a capsid protein having at least 95% amino acid identity to AAVrh10 infringes upon the ‘617 Patent asserted by RegenX. Plaintiffs seek injunctive relief, a judgment of infringement and willful infringement, an unspecified amount of damages that is no less than a reasonable royalty (treble damages), attorneys’ fees and costs, and such other relief as the court deems just and proper. On January 4, 2022, the Court denied Sarepta’s motion to dismiss the case pursuant to Federal Rule of Civil Procedure 12(b)(6) based on the Safe Harbor provision of non-infringement contained in 35 U.S.C. § 271(e)(1). Sarepta answered the Complaint on January 18, 2022, and a case schedule has been set with a trial commencing on January 29, 2024. On July 13, 2021, Nippon Shinyaku Co., Ltd. (“Nippon Shinyaku” or “NS”) filed a lawsuit against the Company in the U.S. District Court for the District of Delaware. NS asserts a claim for breach of contract arising from Sarepta filing seven petitions for Inter Partes Review (“IPR Petitions”) with the Patent Trial and Appeal Board at the USPTO (PTAB Case Nos. IPR2021-01134, IPR2021-01135, IPR2021-01136, IPR2021-01137, IPR2021-01138, IPR2021-01139, IPR2021-01140) in which Sarepta is seeking to invalidate certain NS patents concerning exon 53 skipping technology (U.S. Patent Nos. 9,708,361, 10,385,092, 10,407,461, 10,487,106, 10,647,741, 10,662,217, and 10,683,322, respectively, and collectively the “NS Patents”). In addition, NS asserts claims for patent infringement and willful infringement of each of the NS Patents arising from Sarepta’s alleged activities concerning, including the sale of, its exon 53 skipping product, VYONDYS 53 (golodirsen). NS further seeks a determination of non-infringement by NS arising from NS’s alleged activities concerning, including the sale of, its exon 53 skipping product, Viltepso (viltolarsen) and invalidity of certain patents licensed to the Company from UWA (U.S. Patent Nos. 9,994,851, 10,227,590, and 10,266,827, collectively the “UWA Patents”). NS is seeking legal fees and costs, an unspecified amount of monetary relief (treble damages) attributed to Sarepta’s alleged infringement, and such other relief as the court deems just and proper. NS filed a motion for preliminary injunction solely seeking Sarepta’s withdrawal of the IPR Petitions. The district court denied NS’ motion for preliminary injunction on September 24, 2021, and the U.S. Court of Appeals for the Federal Circuit reversed and remanded the district court on February 8, 2022. The deadline for the Company to seek rehearing of the Federal Circuit decision is March 10, 2022. In January 2022, the PTAB granted institution of all claims of all NS Patents in response to Sarepta’s IPR Petitions and determined that Sarepta has demonstrated a reasonable likelihood of success in proving that the NS Patents are unpatentable. On December 27, 2021, the district court partially granted and denied the motion to dismiss by Sarepta and ordered NS to file a Second Amended Complaint (“SAC”), which it did on January 14, 2022. In the SAC, NS maintains all claims of the original complaint of July 13, 2021, except a determination of non-infringement of the UWA Patents. On January 28, 2022, Sarepta filed its answer to the SAC, with defenses and counterclaims against NS and NS Pharma Inc. that include infringement of the UWA Patents arising from their alleged activities concerning, including the sale of, its exon 53 skipping product, Viltepso (viltolarsen) and breach of contract. Sarepta is also seeking a determination of invalidity of the NS Patents. Sarepta is seeking an award of relief in its defenses to NS’ allegations, a judgment of breach of contract, a determination of invalidity of the NS Patents, a judgment of infringement and willful infringement of the UWA Patents, legal fees and costs, an unspecified amount of monetary relief (treble damages) attributed to NS’ alleged infringement, and such other relief as the court deems just and proper. Case scheduling in district court, including a trial date, will follow.

4 4 23400000 20100000 3300000 21100000 2028-12-31 2 2 2024-12-31 4 22800000 20000000.0 2800000 2026-12-31 The Company has the option to extend the term of the Aldevron Agreements by one year if the Company delivers a written notice of its intention to extend to Aldevron no later than June 1, 2025. Both parties have the right to early terminate without additional penalty. The Company has determined that the Aldevron Agreements do not contain an embedded lease because it does not convey the right to control the use of Aldevron’s facility or related equipment therein. The following table presents non-cancelable contractual obligations arising from long-term contractual arrangements, including obligations related to leases embedded in certain supply agreements: <table style="margin-left:auto;border-spacing:0;table-layout:fixed;width:60.0%;border-collapse:separate;margin-right:auto;"> <tr style="visibility:collapse;"> <td style="width:70.789%;"/> <td style="width:3.576%;"/> <td style="width:2.415%;"/> <td style="width:22.291%;"/> <td style="width:0.929%;"/> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:left;">As of December 31, 2021</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);text-align:left;"> </td> </tr> <tr style="height:8.0pt;"> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td colspan="2" style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;">(in thousands)</td> <td style="background-color:rgba(255,255,255,1);word-break:break-word;vertical-align:bottom;text-align:left;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">2022</td> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">647,124</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">2023</td> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">178,345</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">2024</td> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">138,725</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">2025</td> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;text-align:center;">100,838</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">2026</td> <td style="background-color:rgba(207,240,252,1);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;text-align:center;">54,720</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(255,255,255,1);text-indent:5.0pt;word-break:break-word;vertical-align:bottom;">Thereafter</td> <td style="background-color:rgba(0,0,0,0);text-indent:10.0pt;word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);"> </td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(0,0,0,1);text-align:center;">109,440</td> <td style="background-color:rgba(0,0,0,0);word-break:break-word;vertical-align:bottom;border-bottom:0.500pt solid rgba(255,255,255,0.01);"> </td> </tr> <tr style="height:10.0pt;"> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;">Total manufacturing commitments</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;"> </td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);">$</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(0,0,0,1);text-align:center;">1,229,192</td> <td style="background-color:rgba(207,240,252,1);word-break:break-word;vertical-align:bottom;border-bottom:2.250pt double rgba(255,255,255,0.01);"> </td> </tr> </table>

647124000

178345000

138725000

100838000

54720000

109440000

1229192000

378500000

47900000

40400000

31600000

The risk-free interest rate is estimated using an average of Treasury bill interest rates over a historical period commensurate with the expected term of the option that correlates to the prevailing interest rates at the time of grant. The expected dividend yield is zero as the Company has not paid any dividends to date and does not expect to pay dividends in the future. The expected term is estimated using historical exercise behavior. The expected volatility is the implied volatility in exchange-traded options of the Company’s common stock. The gain (loss) on contingent consideration, net is related to the fair value adjustment of the regulatory-related contingent payments that are accounted for as derivatives. Please see Note 5. Fair Value Measurements for further details. For the years ended December 31, 2021, 2020 and 2019, stock options, RSAs, RSUs and ESPP to purchase approximately 9.7 million, 9.0 million and 9.1 million shares of common stock, respectively, were excluded from the net loss per share calculation as their effect would have been anti-dilutive. The Company accounts for the effect of the 2024 Notes on diluted net earnings per share using the if-converted method as this obligation may be settled in cash or shares at the Company’s option. The effect of potential share settlement is included in the diluted net earnings per share calculation if the effect is more dilutive. During the year ended December 31, 2021, the inclusion of the potential share settlement of the 2024 Notes was anti-dilutive. Accordingly, the potential conversion of 7,763,552 shares has been excluded from the computation of diluted net earnings per share as of December 31, 2021.